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Diabetic kidney disease in Pima Indians.
Diabetes Care 1993; 16(1):335-41DC

Abstract

OBJECTIVE

--To describe the natural history of kidney disease in Pima Indians with NIDDM. RESEARCH DESIGN AND

METHODS

--Review of previous studies describing diabetic kidney disease in this Native-American population and in other populations.

RESULTS

--NIDDM is the leading cause of renal failure in Pima Indians, among whom the incidence of ESRD is 23 times that of the general U.S. population. The high incidence of NIDDM and its early onset in the Pima undoubtedly contribute to this difference. The incidence of overt nephropathy and ESRD, as a function of diabetes duration, is at least as high in Pima Indians with NIDDM as that reported in other populations with IDDM. Furthermore, nearly all of the excess mortality associated with NIDDM is found in individuals with overt nephropathy. Mild elevations of UAE, which may be present even shortly after the onset of diabetes, predict the development of overt nephropathy in diabetic Pimas. Additional predictors include high blood pressure, level of glycemia, duration of diabetes, family history of diabetic nephropathy, and type of diabetes treatment.

CONCLUSIONS

--Diabetic kidney disease is a major cause of morbidity and mortality in Pima Indians. The natural history of diabetic kidney disease in this population is similar, in many ways, to the natural history described in individuals with IDDM.

Authors+Show Affiliations

Department of Biostatistics and Epidemiology, Cleveland Clinic Foundation, Phoenix, AZ 85016.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8422805

Citation

Nelson, R G., et al. "Diabetic Kidney Disease in Pima Indians." Diabetes Care, vol. 16, no. 1, 1993, pp. 335-41.
Nelson RG, Knowler WC, Pettitt DJ, et al. Diabetic kidney disease in Pima Indians. Diabetes Care. 1993;16(1):335-41.
Nelson, R. G., Knowler, W. C., Pettitt, D. J., Saad, M. F., & Bennett, P. H. (1993). Diabetic kidney disease in Pima Indians. Diabetes Care, 16(1), pp. 335-41.
Nelson RG, et al. Diabetic Kidney Disease in Pima Indians. Diabetes Care. 1993;16(1):335-41. PubMed PMID: 8422805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic kidney disease in Pima Indians. AU - Nelson,R G, AU - Knowler,W C, AU - Pettitt,D J, AU - Saad,M F, AU - Bennett,P H, PY - 1993/1/1/pubmed PY - 1993/1/1/medline PY - 1993/1/1/entrez SP - 335 EP - 41 JF - Diabetes care JO - Diabetes Care VL - 16 IS - 1 N2 - OBJECTIVE--To describe the natural history of kidney disease in Pima Indians with NIDDM. RESEARCH DESIGN AND METHODS--Review of previous studies describing diabetic kidney disease in this Native-American population and in other populations. RESULTS--NIDDM is the leading cause of renal failure in Pima Indians, among whom the incidence of ESRD is 23 times that of the general U.S. population. The high incidence of NIDDM and its early onset in the Pima undoubtedly contribute to this difference. The incidence of overt nephropathy and ESRD, as a function of diabetes duration, is at least as high in Pima Indians with NIDDM as that reported in other populations with IDDM. Furthermore, nearly all of the excess mortality associated with NIDDM is found in individuals with overt nephropathy. Mild elevations of UAE, which may be present even shortly after the onset of diabetes, predict the development of overt nephropathy in diabetic Pimas. Additional predictors include high blood pressure, level of glycemia, duration of diabetes, family history of diabetic nephropathy, and type of diabetes treatment. CONCLUSIONS--Diabetic kidney disease is a major cause of morbidity and mortality in Pima Indians. The natural history of diabetic kidney disease in this population is similar, in many ways, to the natural history described in individuals with IDDM. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/8422805/full_citation L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -