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Serum cholesterol and risk of rheumatoid arthritis in a cohort of 52 800 men and women.

Abstract

Recent epidemiological studies have suggested that joint risk factors occur for rheumatoid arthritis (RA) and coronary heart disease. We studied serum cholesterol concentration for its association with the incidence or RA in 28 362 men and 24 444 women free from arthritis at baseline. During a mean follow-up of 21 yr, 161 men and 351 women developed RA. Of these incident cases, 119 men and 229 women were rheumatoid factor (RF) positive. The serum cholesterol concentration was directly proportional to the risk of RF-positive RA among women and RF-negative RA among men; the age-adjusted relative risks (95% confidence intervals) per S.D. (1.4 mM/l) of the cholesterol distribution were 1.20 (1.05-1.38) and 1.56 (1.15-2.10), respectively. No association was observed, however, for RF-negative RA among women or RF-positive RA among men. The results suggest that a still unknown factor closely associated with serum cholesterol may be involved in the aetiology of RA, but complex interactions with sex and RF status seem to occur.

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  • Authors+Show Affiliations

    ,

    National Public Health Institute, Helsinki, Finland.

    , , ,

    Source

    British journal of rheumatology 35:3 1996 Mar pg 255-7

    MeSH

    Adolescent
    Adult
    Aged
    Arthritis, Rheumatoid
    Cholesterol
    Cohort Studies
    Disease Susceptibility
    Female
    Finland
    Humans
    Longitudinal Studies
    Male
    Middle Aged
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8620301

    Citation

    Heliövaara, M, et al. "Serum Cholesterol and Risk of Rheumatoid Arthritis in a Cohort of 52 800 Men and Women." British Journal of Rheumatology, vol. 35, no. 3, 1996, pp. 255-7.
    Heliövaara M, Aho K, Knekt P, et al. Serum cholesterol and risk of rheumatoid arthritis in a cohort of 52 800 men and women. Br J Rheumatol. 1996;35(3):255-7.
    Heliövaara, M., Aho, K., Knekt, P., Reunanen, A., & Aromaa, A. (1996). Serum cholesterol and risk of rheumatoid arthritis in a cohort of 52 800 men and women. British Journal of Rheumatology, 35(3), pp. 255-7.
    Heliövaara M, et al. Serum Cholesterol and Risk of Rheumatoid Arthritis in a Cohort of 52 800 Men and Women. Br J Rheumatol. 1996;35(3):255-7. PubMed PMID: 8620301.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum cholesterol and risk of rheumatoid arthritis in a cohort of 52 800 men and women. AU - Heliövaara,M, AU - Aho,K, AU - Knekt,P, AU - Reunanen,A, AU - Aromaa,A, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 255 EP - 7 JF - British journal of rheumatology JO - Br. J. Rheumatol. VL - 35 IS - 3 N2 - Recent epidemiological studies have suggested that joint risk factors occur for rheumatoid arthritis (RA) and coronary heart disease. We studied serum cholesterol concentration for its association with the incidence or RA in 28 362 men and 24 444 women free from arthritis at baseline. During a mean follow-up of 21 yr, 161 men and 351 women developed RA. Of these incident cases, 119 men and 229 women were rheumatoid factor (RF) positive. The serum cholesterol concentration was directly proportional to the risk of RF-positive RA among women and RF-negative RA among men; the age-adjusted relative risks (95% confidence intervals) per S.D. (1.4 mM/l) of the cholesterol distribution were 1.20 (1.05-1.38) and 1.56 (1.15-2.10), respectively. No association was observed, however, for RF-negative RA among women or RF-positive RA among men. The results suggest that a still unknown factor closely associated with serum cholesterol may be involved in the aetiology of RA, but complex interactions with sex and RF status seem to occur. SN - 0263-7103 UR - https://www.unboundmedicine.com/medline/citation/8620301/full_citation L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -