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Epidemiology of in situ and invasive breast cancer in women aged under 45.

Abstract

The incidence of in situ breast cancer in the USA has increased rapidly in recent years, even among young women. A population-based case-control study of 1616 breast cancer cases aged under 45 in the USA was used to examine risk factors for in situ, local and regional/distant tumours. Almost 60% of in situ tumours were detected by routine mammograms compared with 18% of local tumours and 8% of regional/distant tumours. After adjustment for screening history and established risk factors, family history of breast cancer in a first-degree relative and African-American race were associated with an increased risk of all stages of breast cancer. The associations with nulliparity, a previous breast biopsy and body mass index were significantly stronger for in situ tumours than for local or regional/distant disease. Alcohol consumption was associated with an increasing trend in risk of regional/distant tumours but not of earlier stage tumours, indicating that alcohol may be involved in late-stage events. Analyses by histological type of in situ tumours suggested that both ductal and lobular carcinoma in situ were associated with most established breast cancer risk factors, and the magnitude of association tended to be greater for the ductal form.

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  • Authors+Show Affiliations

    ,

    Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892-7374, USA.

    , , , , , ,

    Source

    British journal of cancer 73:10 1996 May pg 1298-305

    MeSH

    Adult
    Age Factors
    Alcohol Drinking
    Body Mass Index
    Breast Neoplasms
    Carcinoma in Situ
    Carcinoma, Ductal, Breast
    Carcinoma, Lobular
    Case-Control Studies
    Educational Status
    Female
    Humans
    Interviews as Topic
    Mammography
    Menstruation
    Parity
    Registries
    Risk
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8630296

    Citation

    Weiss, H A., et al. "Epidemiology of in Situ and Invasive Breast Cancer in Women Aged Under 45." British Journal of Cancer, vol. 73, no. 10, 1996, pp. 1298-305.
    Weiss HA, Brinton LA, Brogan D, et al. Epidemiology of in situ and invasive breast cancer in women aged under 45. Br J Cancer. 1996;73(10):1298-305.
    Weiss, H. A., Brinton, L. A., Brogan, D., Coates, R. J., Gammon, M. D., Malone, K. E., ... Swanson, C. A. (1996). Epidemiology of in situ and invasive breast cancer in women aged under 45. British Journal of Cancer, 73(10), pp. 1298-305.
    Weiss HA, et al. Epidemiology of in Situ and Invasive Breast Cancer in Women Aged Under 45. Br J Cancer. 1996;73(10):1298-305. PubMed PMID: 8630296.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiology of in situ and invasive breast cancer in women aged under 45. AU - Weiss,H A, AU - Brinton,L A, AU - Brogan,D, AU - Coates,R J, AU - Gammon,M D, AU - Malone,K E, AU - Schoenberg,J B, AU - Swanson,C A, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 1298 EP - 305 JF - British journal of cancer JO - Br. J. Cancer VL - 73 IS - 10 N2 - The incidence of in situ breast cancer in the USA has increased rapidly in recent years, even among young women. A population-based case-control study of 1616 breast cancer cases aged under 45 in the USA was used to examine risk factors for in situ, local and regional/distant tumours. Almost 60% of in situ tumours were detected by routine mammograms compared with 18% of local tumours and 8% of regional/distant tumours. After adjustment for screening history and established risk factors, family history of breast cancer in a first-degree relative and African-American race were associated with an increased risk of all stages of breast cancer. The associations with nulliparity, a previous breast biopsy and body mass index were significantly stronger for in situ tumours than for local or regional/distant disease. Alcohol consumption was associated with an increasing trend in risk of regional/distant tumours but not of earlier stage tumours, indicating that alcohol may be involved in late-stage events. Analyses by histological type of in situ tumours suggested that both ductal and lobular carcinoma in situ were associated with most established breast cancer risk factors, and the magnitude of association tended to be greater for the ductal form. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/8630296/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8630296/ DB - PRIME DP - Unbound Medicine ER -