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Disaccharide digestion and maldigestion.

Abstract

All food carbohydrates are hydrolysed to monosaccharides before transport across the microvillus membrane. The digestion of disaccharides and some oligosaccharides is undertaken by a number of small intestinal brush border enzymes: sucrase-isomaltase, lactase phlorizinhydrolase, maltase-glycoamylase and trehalase. The distribution of the enzymes in the small intestine has been investigated. Different disaccharide maldigestion syndromes have been described. Lactase deficiency in adults is a condition found in the majority of inhabitants of the world. However, the prevalence varies widely between different populations. Sucrase-isomaltase deficiency is a very rare congenital condition except in Greenland. Trehalose maldigestion is likewise rare outside Greenland. Different hypotheses regarding the molecular background of the maldigestion syndromes are discussed.

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Authors+Show Affiliations

,

Dept. of Medical Gastroenterology F, Gentofte University Hospital, Copenhagen, Denmark.

Source

MeSH

Adult
Alaska
Canada
Carbohydrate Metabolism, Inborn Errors
Disaccharidases
Disaccharides
Europe
Greenland
Humans
Intestine, Small
Inuits
Malabsorption Syndromes
Microvilli
Prevalence

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8726284

Citation

Gudmand-Høyer, E, and H Skovbjerg. "Disaccharide Digestion and Maldigestion." Scandinavian Journal of Gastroenterology. Supplement, vol. 216, 1996, pp. 111-21.
Gudmand-Høyer E, Skovbjerg H. Disaccharide digestion and maldigestion. Scand J Gastroenterol Suppl. 1996;216:111-21.
Gudmand-Høyer, E., & Skovbjerg, H. (1996). Disaccharide digestion and maldigestion. Scandinavian Journal of Gastroenterology. Supplement, 216, pp. 111-21.
Gudmand-Høyer E, Skovbjerg H. Disaccharide Digestion and Maldigestion. Scand J Gastroenterol Suppl. 1996;216:111-21. PubMed PMID: 8726284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disaccharide digestion and maldigestion. AU - Gudmand-Høyer,E, AU - Skovbjerg,H, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 111 EP - 21 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 216 N2 - All food carbohydrates are hydrolysed to monosaccharides before transport across the microvillus membrane. The digestion of disaccharides and some oligosaccharides is undertaken by a number of small intestinal brush border enzymes: sucrase-isomaltase, lactase phlorizinhydrolase, maltase-glycoamylase and trehalase. The distribution of the enzymes in the small intestine has been investigated. Different disaccharide maldigestion syndromes have been described. Lactase deficiency in adults is a condition found in the majority of inhabitants of the world. However, the prevalence varies widely between different populations. Sucrase-isomaltase deficiency is a very rare congenital condition except in Greenland. Trehalose maldigestion is likewise rare outside Greenland. Different hypotheses regarding the molecular background of the maldigestion syndromes are discussed. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/8726284/full_citation L2 - https://medlineplus.gov/carbohydratemetabolismdisorders.html DB - PRIME DP - Unbound Medicine ER -