Tags

Type your tag names separated by a space and hit enter

Breast cancer in African American women: epidemiology and tumor biology.
Breast Cancer Res Treat 1996; 40(1):11-24BC

Abstract

This review of published data on the epidemiology, pathology, and molecular biology of breast cancer in African American women seeks to identify how the etiology and presentation of the disease differ from those in white women. The crossover from higher to lower age-specific incidence rates in African American women at age 45 cannot be explained by current data on the distribution of risk factors. Data from six case-control studies suggest that the relative risks associated with both established and probable breast cancer risk factors are similar in African American and white women. Lower survival in African American compared to white women is primarily attributable to diagnosis at a later stage. However, evidence from a number of studies suggests that tumors in African American women may exhibit a more aggressive phenotype, which could also contribute to the survival disparity. Tumors in African American women are more likely to occur at a younger age, to be poorly differentiated and estrogen receptor negative, and to exhibit high grade nuclear atypia, more aggressive histology (more medullary and less lobular), and higher S-phase. Overexpression of p53 and erbB-2 occurs with similar frequency in African American and white women, although limited data suggest the former may exhibit different p53 mutation spectra. One study found high risk associated with a specific CYP1A1 polymorphism in African American but not white women. Additional studies of molecular differences in African American and white women are needed, with multifactorial assessment of the independent effects of molecular and conventional risk attributes.

Authors+Show Affiliations

Lombardi Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8888149

Citation

Trock, B J.. "Breast Cancer in African American Women: Epidemiology and Tumor Biology." Breast Cancer Research and Treatment, vol. 40, no. 1, 1996, pp. 11-24.
Trock BJ. Breast cancer in African American women: epidemiology and tumor biology. Breast Cancer Res Treat. 1996;40(1):11-24.
Trock, B. J. (1996). Breast cancer in African American women: epidemiology and tumor biology. Breast Cancer Research and Treatment, 40(1), pp. 11-24.
Trock BJ. Breast Cancer in African American Women: Epidemiology and Tumor Biology. Breast Cancer Res Treat. 1996;40(1):11-24. PubMed PMID: 8888149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer in African American women: epidemiology and tumor biology. A1 - Trock,B J, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 11 EP - 24 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 40 IS - 1 N2 - This review of published data on the epidemiology, pathology, and molecular biology of breast cancer in African American women seeks to identify how the etiology and presentation of the disease differ from those in white women. The crossover from higher to lower age-specific incidence rates in African American women at age 45 cannot be explained by current data on the distribution of risk factors. Data from six case-control studies suggest that the relative risks associated with both established and probable breast cancer risk factors are similar in African American and white women. Lower survival in African American compared to white women is primarily attributable to diagnosis at a later stage. However, evidence from a number of studies suggests that tumors in African American women may exhibit a more aggressive phenotype, which could also contribute to the survival disparity. Tumors in African American women are more likely to occur at a younger age, to be poorly differentiated and estrogen receptor negative, and to exhibit high grade nuclear atypia, more aggressive histology (more medullary and less lobular), and higher S-phase. Overexpression of p53 and erbB-2 occurs with similar frequency in African American and white women, although limited data suggest the former may exhibit different p53 mutation spectra. One study found high risk associated with a specific CYP1A1 polymorphism in African American but not white women. Additional studies of molecular differences in African American and white women are needed, with multifactorial assessment of the independent effects of molecular and conventional risk attributes. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/8888149/full_citation L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -