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Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus.

Abstract

OBJECTIVES

Because oxidative damage has been implicated in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, this study was designed to see if serum concentrations of alpha tocopherol, beta carotene, and retinol, substances believed to be involved in the prevention or repair of oxidative damage, might be lower among persons who develop rheumatoid arthritis or systemic lupus erythematosus than among those who do not.

METHODS

For this prospective case-control study, persons with rheumatoid arthritis and systemic lupus erythematosus that developed two to 15 years after donating blood for a serum bank in 1974 were designated as cases. For each case, four controls were selected from the serum bank donors, matched for race, sex, and age. Stored serum samples from cases and controls were assayed for alpha tocopherol, beta carotene, and retinol.

RESULTS

Cases of both diseases had lower serum concentrations of alpha tocopherol, beta carotene, and retinol in 1974 than their matched controls. For rheumatoid arthritis, the difference for beta carotene (-29%) was statistically significant.

CONCLUSIONS

These findings support those of a previous study that low antioxidant status is a risk factor for rheumatoid arthritis. They suggest a similar association for systemic lupus erythematosus.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

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    Source

    Annals of the rheumatic diseases 56:5 1997 May pg 323-5

    MeSH

    Adult
    Arthritis, Rheumatoid
    Biomarkers
    Case-Control Studies
    Female
    Humans
    Lupus Erythematosus, Systemic
    Male
    Middle Aged
    Prospective Studies
    Vitamin A
    Vitamin E
    Vitamins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9175934

    Citation

    Comstock, G W., et al. "Serum Concentrations of Alpha Tocopherol, Beta Carotene, and Retinol Preceding the Diagnosis of Rheumatoid Arthritis and Systemic Lupus Erythematosus." Annals of the Rheumatic Diseases, vol. 56, no. 5, 1997, pp. 323-5.
    Comstock GW, Burke AE, Hoffman SC, et al. Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 1997;56(5):323-5.
    Comstock, G. W., Burke, A. E., Hoffman, S. C., Helzlsouer, K. J., Bendich, A., Masi, A. T., ... Gershwin, M. E. (1997). Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases, 56(5), pp. 323-5.
    Comstock GW, et al. Serum Concentrations of Alpha Tocopherol, Beta Carotene, and Retinol Preceding the Diagnosis of Rheumatoid Arthritis and Systemic Lupus Erythematosus. Ann Rheum Dis. 1997;56(5):323-5. PubMed PMID: 9175934.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum concentrations of alpha tocopherol, beta carotene, and retinol preceding the diagnosis of rheumatoid arthritis and systemic lupus erythematosus. AU - Comstock,G W, AU - Burke,A E, AU - Hoffman,S C, AU - Helzlsouer,K J, AU - Bendich,A, AU - Masi,A T, AU - Norkus,E P, AU - Malamet,R L, AU - Gershwin,M E, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 323 EP - 5 JF - Annals of the rheumatic diseases JO - Ann. Rheum. Dis. VL - 56 IS - 5 N2 - OBJECTIVES: Because oxidative damage has been implicated in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, this study was designed to see if serum concentrations of alpha tocopherol, beta carotene, and retinol, substances believed to be involved in the prevention or repair of oxidative damage, might be lower among persons who develop rheumatoid arthritis or systemic lupus erythematosus than among those who do not. METHODS: For this prospective case-control study, persons with rheumatoid arthritis and systemic lupus erythematosus that developed two to 15 years after donating blood for a serum bank in 1974 were designated as cases. For each case, four controls were selected from the serum bank donors, matched for race, sex, and age. Stored serum samples from cases and controls were assayed for alpha tocopherol, beta carotene, and retinol. RESULTS: Cases of both diseases had lower serum concentrations of alpha tocopherol, beta carotene, and retinol in 1974 than their matched controls. For rheumatoid arthritis, the difference for beta carotene (-29%) was statistically significant. CONCLUSIONS: These findings support those of a previous study that low antioxidant status is a risk factor for rheumatoid arthritis. They suggest a similar association for systemic lupus erythematosus. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/9175934/full_citation L2 - http://ard.bmj.com/cgi/pmidlookup?view=long&pmid=9175934 DB - PRIME DP - Unbound Medicine ER -