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Down's syndrome is strongly associated with coeliac disease.
Gut 1997; 40(4):492-6Gut

Abstract

BACKGROUND

There is evidence of an increased prevalence of coeliac disease in Down's syndrome.

AIMS

To investigate the association, patients with Down's syndrome and matched controls were examined.

METHODS

Fifty nine patients with Down's syndrome residing in government institutions in the Hunter region of New South Wales were studied. Four were excluded (terminally ill = 1, uncooperative = 3). Each of 55 patients was matched for age, sex, and residence with a control patient. Patients with both positive IgA and IgG antigliadin antibodies were considered for endoscopical duodenal biopsy.

RESULTS

Twenty one patients and two controls had raised IgA and IgG antibodies (chi 2 = 19.4; p < 0.001). Tissue was obtained in 18 patients. Two had characteristic flat, five pronounced lymphocytic infiltration not diagnostic of coeliac disease, two giardiasis, and eight were normal. In one the tissue was not suitable for analysis. There were few differences between the subgroups in their anthropomorphic, biochemical, or haematological findings.

CONCLUSIONS

The prevalence of coeliac disease in these 51 patients with Down's syndrome is at least two (3.9%; 95% confidence interval (95% CI) 0%-9.2%) and could be as many as seven (13.7%; 95% CI 4.3%-23.2%). In this community the prevalence of coeliac disease in Down's syndrome is increased more than 100-fold (x135-473).

Authors+Show Affiliations

Hunter Region Developmental Disability Service, Stockton Centre, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9176077

Citation

Gale, L, et al. "Down's Syndrome Is Strongly Associated With Coeliac Disease." Gut, vol. 40, no. 4, 1997, pp. 492-6.
Gale L, Wimalaratna H, Brotodiharjo A, et al. Down's syndrome is strongly associated with coeliac disease. Gut. 1997;40(4):492-6.
Gale, L., Wimalaratna, H., Brotodiharjo, A., & Duggan, J. M. (1997). Down's syndrome is strongly associated with coeliac disease. Gut, 40(4), pp. 492-6.
Gale L, et al. Down's Syndrome Is Strongly Associated With Coeliac Disease. Gut. 1997;40(4):492-6. PubMed PMID: 9176077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down's syndrome is strongly associated with coeliac disease. AU - Gale,L, AU - Wimalaratna,H, AU - Brotodiharjo,A, AU - Duggan,J M, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 492 EP - 6 JF - Gut JO - Gut VL - 40 IS - 4 N2 - BACKGROUND: There is evidence of an increased prevalence of coeliac disease in Down's syndrome. AIMS: To investigate the association, patients with Down's syndrome and matched controls were examined. METHODS: Fifty nine patients with Down's syndrome residing in government institutions in the Hunter region of New South Wales were studied. Four were excluded (terminally ill = 1, uncooperative = 3). Each of 55 patients was matched for age, sex, and residence with a control patient. Patients with both positive IgA and IgG antigliadin antibodies were considered for endoscopical duodenal biopsy. RESULTS: Twenty one patients and two controls had raised IgA and IgG antibodies (chi 2 = 19.4; p < 0.001). Tissue was obtained in 18 patients. Two had characteristic flat, five pronounced lymphocytic infiltration not diagnostic of coeliac disease, two giardiasis, and eight were normal. In one the tissue was not suitable for analysis. There were few differences between the subgroups in their anthropomorphic, biochemical, or haematological findings. CONCLUSIONS: The prevalence of coeliac disease in these 51 patients with Down's syndrome is at least two (3.9%; 95% confidence interval (95% CI) 0%-9.2%) and could be as many as seven (13.7%; 95% CI 4.3%-23.2%). In this community the prevalence of coeliac disease in Down's syndrome is increased more than 100-fold (x135-473). SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9176077/full_citation L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=9176077 DB - PRIME DP - Unbound Medicine ER -