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Down's syndrome is strongly associated with coeliac disease.

Abstract

BACKGROUND

There is evidence of an increased prevalence of coeliac disease in Down's syndrome.

AIMS

To investigate the association, patients with Down's syndrome and matched controls were examined.

METHODS

Fifty nine patients with Down's syndrome residing in government institutions in the Hunter region of New South Wales were studied. Four were excluded (terminally ill = 1, uncooperative = 3). Each of 55 patients was matched for age, sex, and residence with a control patient. Patients with both positive IgA and IgG antigliadin antibodies were considered for endoscopical duodenal biopsy.

RESULTS

Twenty one patients and two controls had raised IgA and IgG antibodies (chi 2 = 19.4; p < 0.001). Tissue was obtained in 18 patients. Two had characteristic flat, five pronounced lymphocytic infiltration not diagnostic of coeliac disease, two giardiasis, and eight were normal. In one the tissue was not suitable for analysis. There were few differences between the subgroups in their anthropomorphic, biochemical, or haematological findings.

CONCLUSIONS

The prevalence of coeliac disease in these 51 patients with Down's syndrome is at least two (3.9%; 95% confidence interval (95% CI) 0%-9.2%) and could be as many as seven (13.7%; 95% CI 4.3%-23.2%). In this community the prevalence of coeliac disease in Down's syndrome is increased more than 100-fold (x135-473).

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  • Authors+Show Affiliations

    ,

    Hunter Region Developmental Disability Service, Stockton Centre, NSW, Australia.

    , ,

    Source

    Gut 40:4 1997 Apr pg 492-6

    MeSH

    Adult
    Antibodies
    Celiac Disease
    Comorbidity
    Down Syndrome
    Duodenum
    Female
    Gliadin
    Humans
    Immunoglobulin A
    Immunoglobulin G
    Male
    Middle Aged
    Prevalence

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    9176077

    Citation

    Gale, L, et al. "Down's Syndrome Is Strongly Associated With Coeliac Disease." Gut, vol. 40, no. 4, 1997, pp. 492-6.
    Gale L, Wimalaratna H, Brotodiharjo A, et al. Down's syndrome is strongly associated with coeliac disease. Gut. 1997;40(4):492-6.
    Gale, L., Wimalaratna, H., Brotodiharjo, A., & Duggan, J. M. (1997). Down's syndrome is strongly associated with coeliac disease. Gut, 40(4), pp. 492-6.
    Gale L, et al. Down's Syndrome Is Strongly Associated With Coeliac Disease. Gut. 1997;40(4):492-6. PubMed PMID: 9176077.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Down's syndrome is strongly associated with coeliac disease. AU - Gale,L, AU - Wimalaratna,H, AU - Brotodiharjo,A, AU - Duggan,J M, PY - 1997/4/1/pubmed PY - 1997/4/1/medline PY - 1997/4/1/entrez SP - 492 EP - 6 JF - Gut JO - Gut VL - 40 IS - 4 N2 - BACKGROUND: There is evidence of an increased prevalence of coeliac disease in Down's syndrome. AIMS: To investigate the association, patients with Down's syndrome and matched controls were examined. METHODS: Fifty nine patients with Down's syndrome residing in government institutions in the Hunter region of New South Wales were studied. Four were excluded (terminally ill = 1, uncooperative = 3). Each of 55 patients was matched for age, sex, and residence with a control patient. Patients with both positive IgA and IgG antigliadin antibodies were considered for endoscopical duodenal biopsy. RESULTS: Twenty one patients and two controls had raised IgA and IgG antibodies (chi 2 = 19.4; p < 0.001). Tissue was obtained in 18 patients. Two had characteristic flat, five pronounced lymphocytic infiltration not diagnostic of coeliac disease, two giardiasis, and eight were normal. In one the tissue was not suitable for analysis. There were few differences between the subgroups in their anthropomorphic, biochemical, or haematological findings. CONCLUSIONS: The prevalence of coeliac disease in these 51 patients with Down's syndrome is at least two (3.9%; 95% confidence interval (95% CI) 0%-9.2%) and could be as many as seven (13.7%; 95% CI 4.3%-23.2%). In this community the prevalence of coeliac disease in Down's syndrome is increased more than 100-fold (x135-473). SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9176077/full_citation L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=9176077 DB - PRIME DP - Unbound Medicine ER -