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Epidemiology, pathogenesis, and treatment of the common cold.

Abstract

OBJECTIVE

Reading this article will reinforce the reader's knowledge of the pathogenesis of the common cold. The rationale for current and potential therapies for the common cold are reviewed in the context of current concepts of the pathogenesis of these illnesses.

DATA SOURCES AND STUDY SELECTION

A MEDLINE literature search was done using the search terms common cold, rhinovirus, and viral respiratory infection. The search was restricted to the English language. Articles were selected for review if the title and/or abstract suggested the content was relevant to the subject of this review. The bibliographies of selected articles were used as a source of additional literature.

RESULTS

Recent studies suggest that the host response to the virus is an important contributor to the pathogenesis of the common cold. Inflammatory mediators, especially the pro-inflammatory cytokines, appear to be an important component of this response and present an attractive target for new interventions for common cold therapies. Currently available treatments for the common cold have limited efficacy against specific symptoms. These therapies should be selected to treat the specific symptoms that are perceived to be the most bothersome by the patient.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Pediatrics and Laboratory Medicine, Medical University of South Carolina, Charleston, USA.

    Source

    MeSH

    Adult
    Child, Preschool
    Common Cold
    Humans
    Infant

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    9207716

    Citation

    Turner, R B.. "Epidemiology, Pathogenesis, and Treatment of the Common Cold." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 78, no. 6, 1997, pp. 531-9; quiz 539-40.
    Turner RB. Epidemiology, pathogenesis, and treatment of the common cold. Ann Allergy Asthma Immunol. 1997;78(6):531-9; quiz 539-40.
    Turner, R. B. (1997). Epidemiology, pathogenesis, and treatment of the common cold. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 78(6), pp. 531-9; quiz 539-40.
    Turner RB. Epidemiology, Pathogenesis, and Treatment of the Common Cold. Ann Allergy Asthma Immunol. 1997;78(6):531-9; quiz 539-40. PubMed PMID: 9207716.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiology, pathogenesis, and treatment of the common cold. A1 - Turner,R B, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 531-9; quiz 539-40 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 78 IS - 6 N2 - OBJECTIVE: Reading this article will reinforce the reader's knowledge of the pathogenesis of the common cold. The rationale for current and potential therapies for the common cold are reviewed in the context of current concepts of the pathogenesis of these illnesses. DATA SOURCES AND STUDY SELECTION: A MEDLINE literature search was done using the search terms common cold, rhinovirus, and viral respiratory infection. The search was restricted to the English language. Articles were selected for review if the title and/or abstract suggested the content was relevant to the subject of this review. The bibliographies of selected articles were used as a source of additional literature. RESULTS: Recent studies suggest that the host response to the virus is an important contributor to the pathogenesis of the common cold. Inflammatory mediators, especially the pro-inflammatory cytokines, appear to be an important component of this response and present an attractive target for new interventions for common cold therapies. Currently available treatments for the common cold have limited efficacy against specific symptoms. These therapies should be selected to treat the specific symptoms that are perceived to be the most bothersome by the patient. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/9207716/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)63213-9 DB - PRIME DP - Unbound Medicine ER -