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Pre-illness dietary factors in inflammatory bowel disease.

Abstract

BACKGROUND

The effect of environmental factors has been demonstrated in the pathogenesis of inflammatory bowel disease (IBD). Nutrition may be one of them.

AIM

To investigate the pre-illness diet in patients with recent IBD in comparison with matched population and clinic controls.

METHODS

Quantified dietary histories were obtained from 87 patients with recent IBD (54 ulcerative colitis (UC) and 33 Crohn's disease (CD)) and 144 controls. Odds ratios (OR) for IBD were derived for intake levels of various foods.

RESULTS

A high sucrose consumption was associated with an increased risk for IBD (OR 2.85 (p = 0.03) against population controls and 5.3 (p = 0.00) against clinic controls). Lactose consumption showed no effect while fructose intake was negatively associated with risk for IBD (NS). Similar trends were noted in UC and CD. A high fat intake was associated with an increased risk for UC; this was particularly marked for animal fat (OR 4.09, p = 0.02) and cholesterol (OR 4.57, p = 0.02). A high intake of fluids (p = 0.04), magnesium (p = 0.04), vitamin C, and fruits (NS) was negatively associated with the risk for IBD, while a positive association was found for retinol (p = 0.01). Most of the findings were similar in UC and CD except for potassium and vegetable consumption which showed a negative association only with risk for CD.

CONCLUSIONS

An association was found between pre-illness diet and subsequent development of UC and CD. The effect of dietary components may be primary or modulatory.

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  • Authors+Show Affiliations

    ,

    Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Israel.

    , , , ,

    Source

    Gut 40:6 1997 Jun pg 754-60

    MeSH

    Adult
    Case-Control Studies
    Colitis, Ulcerative
    Crohn Disease
    Diet
    Dietary Carbohydrates
    Dietary Fats
    Dietary Proteins
    Female
    Humans
    Inflammatory Bowel Diseases
    Male
    Micronutrients
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    9245929

    Citation

    Reif, S, et al. "Pre-illness Dietary Factors in Inflammatory Bowel Disease." Gut, vol. 40, no. 6, 1997, pp. 754-60.
    Reif S, Klein I, Lubin F, et al. Pre-illness dietary factors in inflammatory bowel disease. Gut. 1997;40(6):754-60.
    Reif, S., Klein, I., Lubin, F., Farbstein, M., Hallak, A., & Gilat, T. (1997). Pre-illness dietary factors in inflammatory bowel disease. Gut, 40(6), pp. 754-60.
    Reif S, et al. Pre-illness Dietary Factors in Inflammatory Bowel Disease. Gut. 1997;40(6):754-60. PubMed PMID: 9245929.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pre-illness dietary factors in inflammatory bowel disease. AU - Reif,S, AU - Klein,I, AU - Lubin,F, AU - Farbstein,M, AU - Hallak,A, AU - Gilat,T, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 754 EP - 60 JF - Gut JO - Gut VL - 40 IS - 6 N2 - BACKGROUND: The effect of environmental factors has been demonstrated in the pathogenesis of inflammatory bowel disease (IBD). Nutrition may be one of them. AIM: To investigate the pre-illness diet in patients with recent IBD in comparison with matched population and clinic controls. METHODS: Quantified dietary histories were obtained from 87 patients with recent IBD (54 ulcerative colitis (UC) and 33 Crohn's disease (CD)) and 144 controls. Odds ratios (OR) for IBD were derived for intake levels of various foods. RESULTS: A high sucrose consumption was associated with an increased risk for IBD (OR 2.85 (p = 0.03) against population controls and 5.3 (p = 0.00) against clinic controls). Lactose consumption showed no effect while fructose intake was negatively associated with risk for IBD (NS). Similar trends were noted in UC and CD. A high fat intake was associated with an increased risk for UC; this was particularly marked for animal fat (OR 4.09, p = 0.02) and cholesterol (OR 4.57, p = 0.02). A high intake of fluids (p = 0.04), magnesium (p = 0.04), vitamin C, and fruits (NS) was negatively associated with the risk for IBD, while a positive association was found for retinol (p = 0.01). Most of the findings were similar in UC and CD except for potassium and vegetable consumption which showed a negative association only with risk for CD. CONCLUSIONS: An association was found between pre-illness diet and subsequent development of UC and CD. The effect of dietary components may be primary or modulatory. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9245929/full_citation L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=9245929 DB - PRIME DP - Unbound Medicine ER -