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Epidemiology of hepatitis C.

Abstract

In the United States, the annual number of newly acquired acute hepatitis C virus (HCV) infections has declined from an estimated 180,000 in the mid 1980s to an estimated 28,000 in 1995. Approximately 25% to 30% of these infections are clinically apparent cases that are sufficiently symptomatic to gain medical attention. Deaths from fulminant hepatitis C are rare. The prevalence of antibody to HCV (anti-HCV) in the general population of the United States is 1.8%, corresponding to an estimated 3.9 million Americans infected with HCV, and an estimated 8,000 to 10,000 deaths each year result from HCV-associated chronic liver disease. HCV infection affects persons of all ages, but most acute cases of hepatitis C and the highest prevalence of anti-HCV are found among young adults. The highest proportion both of incident cases and prevalent infections is among whites, but the highest incidence and prevalence rates are among non-white racial/ethnic groups. In the past, transfusion of blood and blood products was an important source of HCV transmission, but currently, high-risk drug and sexual exposures account for most HCV transmission. Although the incidence of acute hepatitis C has declined, there is a large reservoir of chronically infected Americans who can serve as a source of transmission to others and who are at risk of the severe consequences of chronic liver disease.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

    Source

    Hepatology (Baltimore, Md.) 26:3 Suppl 1 1997 Sep pg 62S-65S

    MeSH

    Hepatitis C
    Humans
    Incidence
    Prevalence
    Risk Factors

    Pub Type(s)

    Consensus Development Conference
    Journal Article
    Review

    Language

    eng

    PubMed ID

    9305666

    Citation

    Alter, M J.. "Epidemiology of Hepatitis C." Hepatology (Baltimore, Md.), vol. 26, no. 3 Suppl 1, 1997, 62S-65S.
    Alter MJ. Epidemiology of hepatitis C. Hepatology. 1997;26(3 Suppl 1):62S-65S.
    Alter, M. J. (1997). Epidemiology of hepatitis C. Hepatology (Baltimore, Md.), 26(3 Suppl 1), 62S-65S.
    Alter MJ. Epidemiology of Hepatitis C. Hepatology. 1997;26(3 Suppl 1):62S-65S. PubMed PMID: 9305666.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiology of hepatitis C. A1 - Alter,M J, PY - 1997/9/26/pubmed PY - 1997/9/26/medline PY - 1997/9/26/entrez SP - 62S EP - 65S JF - Hepatology (Baltimore, Md.) JO - Hepatology VL - 26 IS - 3 Suppl 1 N2 - In the United States, the annual number of newly acquired acute hepatitis C virus (HCV) infections has declined from an estimated 180,000 in the mid 1980s to an estimated 28,000 in 1995. Approximately 25% to 30% of these infections are clinically apparent cases that are sufficiently symptomatic to gain medical attention. Deaths from fulminant hepatitis C are rare. The prevalence of antibody to HCV (anti-HCV) in the general population of the United States is 1.8%, corresponding to an estimated 3.9 million Americans infected with HCV, and an estimated 8,000 to 10,000 deaths each year result from HCV-associated chronic liver disease. HCV infection affects persons of all ages, but most acute cases of hepatitis C and the highest prevalence of anti-HCV are found among young adults. The highest proportion both of incident cases and prevalent infections is among whites, but the highest incidence and prevalence rates are among non-white racial/ethnic groups. In the past, transfusion of blood and blood products was an important source of HCV transmission, but currently, high-risk drug and sexual exposures account for most HCV transmission. Although the incidence of acute hepatitis C has declined, there is a large reservoir of chronically infected Americans who can serve as a source of transmission to others and who are at risk of the severe consequences of chronic liver disease. SN - 0270-9139 UR - https://www.unboundmedicine.com/medline/citation/9305666/full_citation L2 - https://doi.org/10.1002/hep.510260711 DB - PRIME DP - Unbound Medicine ER -