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A reference standard for plasma proteins is required for nutritional assessment of adult burn patients.

Abstract

Plasma levels of visceral proteins (VP) are commonly used for evaluation of nutritional status. Low values observed in burn patients are caused by several factors including microvascular hyper-permeability and inflammatory processes. The aim of the study was to define a range of standard values specific to burn patients. Retrospective review: from days post-burn 12 to 43, four VP and three acute phase reactants (APR) were measured twice a week, in the plasma of 107 burn patients. From these data, standard' values were determined in respect with burn surface area (BSA) and post-burn time. The results were that the VP increase and APR decrease linearly during the study. Correlation between plasma proteins and BSA or post-burn day, change from protein to protein. Albumin and transferrin are less sensitive than prealbumin and especially retinol binding protein to variations of APR, but transferrin lacks of specificity. The conclusion of the study was that plasma levels of VP have to be compared to reference standard values. When levels lower than theoretical values are observed, simultaneous APR values (especially C reactive protein) have to be compared to their own reference standard, in order to separate nutritional from inflammatory effects.

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  • Authors+Show Affiliations

    ,

    Department of Anesthesiology and Regional Burn Center, Hôpital de la Conception, Marseille, France.

    , , , ,

    Source

    MeSH

    Adult
    Biomarkers
    Blood Proteins
    Burns
    Female
    Follow-Up Studies
    Humans
    Injury Severity Score
    Male
    Middle Aged
    Nutrition Assessment
    Nutritional Requirements
    Nutritional Support
    Reference Standards
    Retrospective Studies
    Treatment Outcome

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    9688199

    Citation

    Manelli, J C., et al. "A Reference Standard for Plasma Proteins Is Required for Nutritional Assessment of Adult Burn Patients." Burns : Journal of the International Society for Burn Injuries, vol. 24, no. 4, 1998, pp. 337-45.
    Manelli JC, Badetti C, Botti G, et al. A reference standard for plasma proteins is required for nutritional assessment of adult burn patients. Burns. 1998;24(4):337-45.
    Manelli, J. C., Badetti, C., Botti, G., Golstein, M. M., Bernini, V., & Bernard, D. (1998). A reference standard for plasma proteins is required for nutritional assessment of adult burn patients. Burns : Journal of the International Society for Burn Injuries, 24(4), pp. 337-45.
    Manelli JC, et al. A Reference Standard for Plasma Proteins Is Required for Nutritional Assessment of Adult Burn Patients. Burns. 1998;24(4):337-45. PubMed PMID: 9688199.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A reference standard for plasma proteins is required for nutritional assessment of adult burn patients. AU - Manelli,J C, AU - Badetti,C, AU - Botti,G, AU - Golstein,M M, AU - Bernini,V, AU - Bernard,D, PY - 1998/8/4/pubmed PY - 1998/8/4/medline PY - 1998/8/4/entrez SP - 337 EP - 45 JF - Burns : journal of the International Society for Burn Injuries JO - Burns VL - 24 IS - 4 N2 - Plasma levels of visceral proteins (VP) are commonly used for evaluation of nutritional status. Low values observed in burn patients are caused by several factors including microvascular hyper-permeability and inflammatory processes. The aim of the study was to define a range of standard values specific to burn patients. Retrospective review: from days post-burn 12 to 43, four VP and three acute phase reactants (APR) were measured twice a week, in the plasma of 107 burn patients. From these data, standard' values were determined in respect with burn surface area (BSA) and post-burn time. The results were that the VP increase and APR decrease linearly during the study. Correlation between plasma proteins and BSA or post-burn day, change from protein to protein. Albumin and transferrin are less sensitive than prealbumin and especially retinol binding protein to variations of APR, but transferrin lacks of specificity. The conclusion of the study was that plasma levels of VP have to be compared to reference standard values. When levels lower than theoretical values are observed, simultaneous APR values (especially C reactive protein) have to be compared to their own reference standard, in order to separate nutritional from inflammatory effects. SN - 0305-4179 UR - https://www.unboundmedicine.com/medline/citation/9688199/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S030541799800031X DB - PRIME DP - Unbound Medicine ER -