Tags

Type your tag names separated by a space and hit enter

Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial.
Am J Clin Nutr 1998; 68(2):365-71AJ

Abstract

Infections remain the leading cause of death after major burns. Trace elements are involved in immunity and burn patients suffer acute trace element depletion after injury. In a previous nonrandomized study, trace element supplementation was associated with increased leukocyte counts and shortened hospital stays. This randomized, placebo-controlled trial studied clinical and immune effects of trace element supplements. Twenty patients, aged 40 +/- 16 y (mean +/- SD), burned on 48 +/- 17% of their body surfaces, were studied for 30 d after injury. They consumed either standard trace element intakes plus supplements (40.4 micromol Cu, 2.9 micromol Se, and 406 micromol Zn; group TE) or standard trace element intakes plus placebo (20 micromol Cu, 0.4 micromol Se, and 100 micromol Zn; group C) for 8 d. Demographic data were similar for both groups. Mean plasma copper and zinc concentrations were below normal until days 20 and 15, respectively (NS). Plasma selenium remained normal for group TE but decreased for group C (P < 0.05 on days 1 and 5). Total leukocyte counts tended to be higher in group TE because of higher neutrophil counts. Proliferation to mitogens was depressed compared with healthy control subjects (NS). The number of infections per patient was significantly (P < 0.05) lower in group TE (1.9 +/- 0.9) than in group C (3.1 +/- 1.1) because of fewer pulmonary infections. Early trace element supplementation appears beneficial after major burns; it was associated with a significant decrease in the number of bronchopneumonia infections and with a shorter hospital stay when data were normalized for burn size.

Authors+Show Affiliations

Surgical ICU and Burns Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Mette.Berger@chuv.hospvd.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9701195

Citation

Berger, M M., et al. "Trace Element Supplementation Modulates Pulmonary Infection Rates After Major Burns: a Double-blind, Placebo-controlled Trial." The American Journal of Clinical Nutrition, vol. 68, no. 2, 1998, pp. 365-71.
Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr. 1998;68(2):365-71.
Berger, M. M., Spertini, F., Shenkin, A., Wardle, C., Wiesner, L., Schindler, C., & Chiolero, R. L. (1998). Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. The American Journal of Clinical Nutrition, 68(2), pp. 365-71.
Berger MM, et al. Trace Element Supplementation Modulates Pulmonary Infection Rates After Major Burns: a Double-blind, Placebo-controlled Trial. Am J Clin Nutr. 1998;68(2):365-71. PubMed PMID: 9701195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. AU - Berger,M M, AU - Spertini,F, AU - Shenkin,A, AU - Wardle,C, AU - Wiesner,L, AU - Schindler,C, AU - Chiolero,R L, PY - 1998/8/13/pubmed PY - 1998/8/13/medline PY - 1998/8/13/entrez SP - 365 EP - 71 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 2 N2 - Infections remain the leading cause of death after major burns. Trace elements are involved in immunity and burn patients suffer acute trace element depletion after injury. In a previous nonrandomized study, trace element supplementation was associated with increased leukocyte counts and shortened hospital stays. This randomized, placebo-controlled trial studied clinical and immune effects of trace element supplements. Twenty patients, aged 40 +/- 16 y (mean +/- SD), burned on 48 +/- 17% of their body surfaces, were studied for 30 d after injury. They consumed either standard trace element intakes plus supplements (40.4 micromol Cu, 2.9 micromol Se, and 406 micromol Zn; group TE) or standard trace element intakes plus placebo (20 micromol Cu, 0.4 micromol Se, and 100 micromol Zn; group C) for 8 d. Demographic data were similar for both groups. Mean plasma copper and zinc concentrations were below normal until days 20 and 15, respectively (NS). Plasma selenium remained normal for group TE but decreased for group C (P < 0.05 on days 1 and 5). Total leukocyte counts tended to be higher in group TE because of higher neutrophil counts. Proliferation to mitogens was depressed compared with healthy control subjects (NS). The number of infections per patient was significantly (P < 0.05) lower in group TE (1.9 +/- 0.9) than in group C (3.1 +/- 1.1) because of fewer pulmonary infections. Early trace element supplementation appears beneficial after major burns; it was associated with a significant decrease in the number of bronchopneumonia infections and with a shorter hospital stay when data were normalized for burn size. SN - 0002-9165 UR - http://www.unboundmedicine.com/medline/citation/9701195/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.2.365 DB - PRIME DP - Unbound Medicine ER -