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Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial.

Abstract

Infections remain the leading cause of death after major burns. Trace elements are involved in immunity and burn patients suffer acute trace element depletion after injury. In a previous nonrandomized study, trace element supplementation was associated with increased leukocyte counts and shortened hospital stays. This randomized, placebo-controlled trial studied clinical and immune effects of trace element supplements. Twenty patients, aged 40 +/- 16 y (mean +/- SD), burned on 48 +/- 17% of their body surfaces, were studied for 30 d after injury. They consumed either standard trace element intakes plus supplements (40.4 micromol Cu, 2.9 micromol Se, and 406 micromol Zn; group TE) or standard trace element intakes plus placebo (20 micromol Cu, 0.4 micromol Se, and 100 micromol Zn; group C) for 8 d. Demographic data were similar for both groups. Mean plasma copper and zinc concentrations were below normal until days 20 and 15, respectively (NS). Plasma selenium remained normal for group TE but decreased for group C (P < 0.05 on days 1 and 5). Total leukocyte counts tended to be higher in group TE because of higher neutrophil counts. Proliferation to mitogens was depressed compared with healthy control subjects (NS). The number of infections per patient was significantly (P < 0.05) lower in group TE (1.9 +/- 0.9) than in group C (3.1 +/- 1.1) because of fewer pulmonary infections. Early trace element supplementation appears beneficial after major burns; it was associated with a significant decrease in the number of bronchopneumonia infections and with a shorter hospital stay when data were normalized for burn size.

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  • Authors+Show Affiliations

    ,

    Surgical ICU and Burns Centre, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Mette.Berger@chuv.hospvd.ch

    , , , , ,

    Source

    MeSH

    Adult
    Burns
    Dietary Supplements
    Double-Blind Method
    Female
    Humans
    Leukocyte Count
    Male
    Middle Aged
    Pneumonia
    Trace Elements

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9701195

    Citation

    Berger, M M., et al. "Trace Element Supplementation Modulates Pulmonary Infection Rates After Major Burns: a Double-blind, Placebo-controlled Trial." The American Journal of Clinical Nutrition, vol. 68, no. 2, 1998, pp. 365-71.
    Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr. 1998;68(2):365-71.
    Berger, M. M., Spertini, F., Shenkin, A., Wardle, C., Wiesner, L., Schindler, C., & Chiolero, R. L. (1998). Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. The American Journal of Clinical Nutrition, 68(2), pp. 365-71.
    Berger MM, et al. Trace Element Supplementation Modulates Pulmonary Infection Rates After Major Burns: a Double-blind, Placebo-controlled Trial. Am J Clin Nutr. 1998;68(2):365-71. PubMed PMID: 9701195.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. AU - Berger,M M, AU - Spertini,F, AU - Shenkin,A, AU - Wardle,C, AU - Wiesner,L, AU - Schindler,C, AU - Chiolero,R L, PY - 1998/8/13/pubmed PY - 1998/8/13/medline PY - 1998/8/13/entrez SP - 365 EP - 71 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 68 IS - 2 N2 - Infections remain the leading cause of death after major burns. Trace elements are involved in immunity and burn patients suffer acute trace element depletion after injury. In a previous nonrandomized study, trace element supplementation was associated with increased leukocyte counts and shortened hospital stays. This randomized, placebo-controlled trial studied clinical and immune effects of trace element supplements. Twenty patients, aged 40 +/- 16 y (mean +/- SD), burned on 48 +/- 17% of their body surfaces, were studied for 30 d after injury. They consumed either standard trace element intakes plus supplements (40.4 micromol Cu, 2.9 micromol Se, and 406 micromol Zn; group TE) or standard trace element intakes plus placebo (20 micromol Cu, 0.4 micromol Se, and 100 micromol Zn; group C) for 8 d. Demographic data were similar for both groups. Mean plasma copper and zinc concentrations were below normal until days 20 and 15, respectively (NS). Plasma selenium remained normal for group TE but decreased for group C (P < 0.05 on days 1 and 5). Total leukocyte counts tended to be higher in group TE because of higher neutrophil counts. Proliferation to mitogens was depressed compared with healthy control subjects (NS). The number of infections per patient was significantly (P < 0.05) lower in group TE (1.9 +/- 0.9) than in group C (3.1 +/- 1.1) because of fewer pulmonary infections. Early trace element supplementation appears beneficial after major burns; it was associated with a significant decrease in the number of bronchopneumonia infections and with a shorter hospital stay when data were normalized for burn size. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/9701195/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/68.2.365 DB - PRIME DP - Unbound Medicine ER -