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5-Hydroxytryptophan: a clinically-effective serotonin precursor.
Altern Med Rev 1998; 3(4):271-80AM

Abstract

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and is not affected by the presence of other amino acids; therefore it may be taken with meals without reducing its effectiveness. Unlike LT, 5-HTP cannot be shunted into niacin or protein production. Therapeutic use of 5-HTP bypasses the conversion of LT into 5-HTP by the enzyme tryptophan hydroxylase, which is the rate-limiting step in the synthesis of serotonin. 5-HTP is well absorbed from an oral dose, with about 70 percent ending up in the bloodstream. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. In the CNS, serotonin levels have been implicated in the regulation of sleep, depression, anxiety, aggression, appetite, temperature, sexual behaviour, and pain sensation. Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia.

Authors+Show Affiliations

73541.2166@compuserve.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9727088

Citation

Birdsall, T C.. "5-Hydroxytryptophan: a Clinically-effective Serotonin Precursor." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 3, no. 4, 1998, pp. 271-80.
Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3(4):271-80.
Birdsall, T. C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative Medicine Review : a Journal of Clinical Therapeutic, 3(4), pp. 271-80.
Birdsall TC. 5-Hydroxytryptophan: a Clinically-effective Serotonin Precursor. Altern Med Rev. 1998;3(4):271-80. PubMed PMID: 9727088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-Hydroxytryptophan: a clinically-effective serotonin precursor. A1 - Birdsall,T C, PY - 1998/9/4/pubmed PY - 1998/9/4/medline PY - 1998/9/4/entrez SP - 271 EP - 80 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 3 IS - 4 N2 - 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite of the essential amino acid L-tryptophan (LT) in the biosynthesis of serotonin. Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and is not affected by the presence of other amino acids; therefore it may be taken with meals without reducing its effectiveness. Unlike LT, 5-HTP cannot be shunted into niacin or protein production. Therapeutic use of 5-HTP bypasses the conversion of LT into 5-HTP by the enzyme tryptophan hydroxylase, which is the rate-limiting step in the synthesis of serotonin. 5-HTP is well absorbed from an oral dose, with about 70 percent ending up in the bloodstream. It easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin. In the CNS, serotonin levels have been implicated in the regulation of sleep, depression, anxiety, aggression, appetite, temperature, sexual behaviour, and pain sensation. Therapeutic administration of 5-HTP has been shown to be effective in treating a wide variety of conditions, including depression, fibromyalgia, binge eating associated with obesity, chronic headaches, and insomnia. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/9727088/full_citation L2 - http://archive.foundationalmedicinereview.com/publications/3/4/271.pdf DB - PRIME DP - Unbound Medicine ER -