Tags

Type your tag names separated by a space and hit enter

Physical activity and benign prostatic hyperplasia.

Abstract

BACKGROUND

Benign prostatic hyperplasia (BPH) leading to prostatic enlargement and lower urinary tract symptoms is highly prevalent among older men. Sympathetic nervous system activity, which is decreased by physical activity, is associated with increased prostatic smooth-muscle tone and prostatic symptoms. Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study.

METHODS

We observed men who were aged 40 to 75 years at baseline in 1986 for subsequent incidence of surgery for BPH. The men were free of diagnosed cancer, including prostate cancer at baseline and during follow-up, had not had a radical prostatectomy, and provided data on physical activity. Cases were men who under-went BPH surgery between 1986 and 1994 (n = 1890) or, among those who did not have surgery, who scored 15 or more points of 35 (n = 1853) on 7 questions about lower urinary tract symptoms modified from the American Urological Association Symptom Index. Noncases were men who scored 7 points or less (n = 21745). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from multiple logistic regression models.

RESULTS

After controlling for age, race or ethnicity, alcohol consumption, and smoking, physical activity was inversely related with total BPH (extreme quintiles: OR, 0.75; 95% CI, 0.67-0.85; P for trend, <.001), surgery for BPH (OR, 0.76; 95% CI, 0.64-0.90; P for trend, <.001), and symptomatic BPH (OR, 0.75; 95% CI, 0.64-0.87; P for trend, <.001). Walking, the most prevalent activity, was inversely related to BPH risk; men who walked 2 to 3 h/wk had a 25% lower risk of total BPH.

CONCLUSION

Our results indicate that more physically active men have a lower frequency of lower urinary tract symptoms.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA. elizabeth.platz@channing.harvard.edu

    , , , , ,

    Source

    Archives of internal medicine 158:21 1998 Nov 23 pg 2349-56

    MeSH

    Adult
    Age Factors
    Aged
    Alcohol Drinking
    Confidence Intervals
    Continental Population Groups
    Ethnic Groups
    Exercise
    Follow-Up Studies
    Humans
    Incidence
    Logistic Models
    Male
    Middle Aged
    Muscle Tonus
    Muscle, Smooth
    Odds Ratio
    Prevalence
    Prostatic Hyperplasia
    Risk Factors
    Smoking
    Sympathetic Nervous System
    Walking

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9827786

    Citation

    Platz, E A., et al. "Physical Activity and Benign Prostatic Hyperplasia." Archives of Internal Medicine, vol. 158, no. 21, 1998, pp. 2349-56.
    Platz EA, Kawachi I, Rimm EB, et al. Physical activity and benign prostatic hyperplasia. Arch Intern Med. 1998;158(21):2349-56.
    Platz, E. A., Kawachi, I., Rimm, E. B., Colditz, G. A., Stampfer, M. J., Willett, W. C., & Giovannucci, E. (1998). Physical activity and benign prostatic hyperplasia. Archives of Internal Medicine, 158(21), pp. 2349-56.
    Platz EA, et al. Physical Activity and Benign Prostatic Hyperplasia. Arch Intern Med. 1998 Nov 23;158(21):2349-56. PubMed PMID: 9827786.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity and benign prostatic hyperplasia. AU - Platz,E A, AU - Kawachi,I, AU - Rimm,E B, AU - Colditz,G A, AU - Stampfer,M J, AU - Willett,W C, AU - Giovannucci,E, PY - 1998/11/25/pubmed PY - 1998/11/25/medline PY - 1998/11/25/entrez SP - 2349 EP - 56 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 158 IS - 21 N2 - BACKGROUND: Benign prostatic hyperplasia (BPH) leading to prostatic enlargement and lower urinary tract symptoms is highly prevalent among older men. Sympathetic nervous system activity, which is decreased by physical activity, is associated with increased prostatic smooth-muscle tone and prostatic symptoms. Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study. METHODS: We observed men who were aged 40 to 75 years at baseline in 1986 for subsequent incidence of surgery for BPH. The men were free of diagnosed cancer, including prostate cancer at baseline and during follow-up, had not had a radical prostatectomy, and provided data on physical activity. Cases were men who under-went BPH surgery between 1986 and 1994 (n = 1890) or, among those who did not have surgery, who scored 15 or more points of 35 (n = 1853) on 7 questions about lower urinary tract symptoms modified from the American Urological Association Symptom Index. Noncases were men who scored 7 points or less (n = 21745). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from multiple logistic regression models. RESULTS: After controlling for age, race or ethnicity, alcohol consumption, and smoking, physical activity was inversely related with total BPH (extreme quintiles: OR, 0.75; 95% CI, 0.67-0.85; P for trend, <.001), surgery for BPH (OR, 0.76; 95% CI, 0.64-0.90; P for trend, <.001), and symptomatic BPH (OR, 0.75; 95% CI, 0.64-0.87; P for trend, <.001). Walking, the most prevalent activity, was inversely related to BPH risk; men who walked 2 to 3 h/wk had a 25% lower risk of total BPH. CONCLUSION: Our results indicate that more physically active men have a lower frequency of lower urinary tract symptoms. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/9827786/full_citation L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/158/pg/2349 DB - PRIME DP - Unbound Medicine ER -