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Diagnostic criteria for Parkinson disease.
Arch Neurol 1999; 56(1):33-9AN

Abstract

The clinical diagnosis of Parkinson disease (PD) is based on the identification of some combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural instability, but few attempts have been made to develop explicit diagnostic criteria. We propose a clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD. Three levels of diagnostic confidence are differentiated: Definite, Probable, and Possible. The diagnoses of Possible and Probable PD are based on clinical criteria alone. Neuropathologic confirmation is required for the diagnosis of Definite PD in patients with the clinical diagnosis of Possible or Probable PD. Criteria for histopathologic confirmation of PD are also presented.

Authors+Show Affiliations

Department of Neurology, University of Michigan, Ann Arbor, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9923759

Citation

Gelb, D J., et al. "Diagnostic Criteria for Parkinson Disease." Archives of Neurology, vol. 56, no. 1, 1999, pp. 33-9.
Gelb DJ, Oliver E, Gilman S. Diagnostic criteria for Parkinson disease. Arch Neurol. 1999;56(1):33-9.
Gelb, D. J., Oliver, E., & Gilman, S. (1999). Diagnostic criteria for Parkinson disease. Archives of Neurology, 56(1), pp. 33-9.
Gelb DJ, Oliver E, Gilman S. Diagnostic Criteria for Parkinson Disease. Arch Neurol. 1999;56(1):33-9. PubMed PMID: 9923759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic criteria for Parkinson disease. AU - Gelb,D J, AU - Oliver,E, AU - Gilman,S, PY - 1999/1/29/pubmed PY - 1999/1/29/medline PY - 1999/1/29/entrez SP - 33 EP - 9 JF - Archives of neurology JO - Arch. Neurol. VL - 56 IS - 1 N2 - The clinical diagnosis of Parkinson disease (PD) is based on the identification of some combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural instability, but few attempts have been made to develop explicit diagnostic criteria. We propose a clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD. Three levels of diagnostic confidence are differentiated: Definite, Probable, and Possible. The diagnoses of Possible and Probable PD are based on clinical criteria alone. Neuropathologic confirmation is required for the diagnosis of Definite PD in patients with the clinical diagnosis of Possible or Probable PD. Criteria for histopathologic confirmation of PD are also presented. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/9923759/full_citation L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/56/pg/33 DB - PRIME DP - Unbound Medicine ER -