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Diagnostic criteria for Parkinson disease.

Abstract

The clinical diagnosis of Parkinson disease (PD) is based on the identification of some combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural instability, but few attempts have been made to develop explicit diagnostic criteria. We propose a clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD. Three levels of diagnostic confidence are differentiated: Definite, Probable, and Possible. The diagnoses of Possible and Probable PD are based on clinical criteria alone. Neuropathologic confirmation is required for the diagnosis of Definite PD in patients with the clinical diagnosis of Possible or Probable PD. Criteria for histopathologic confirmation of PD are also presented.

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  • Publisher Full Text
  • Authors

    , ,

    Source

    Archives of neurology 56:1 1999 Jan pg 33-9

    MeSH

    Antiparkinson Agents
    Diagnostic Imaging
    Humans
    Levodopa
    Parkinson Disease
    Posture
    Probability
    Tremor

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    9923759

    Citation

    TY - JOUR T1 - Diagnostic criteria for Parkinson disease. AU - Gelb,D J, AU - Oliver,E, AU - Gilman,S, PY - 1999/1/29/pubmed PY - 1999/1/29/medline PY - 1999/1/29/entrez SP - 33 EP - 9 JF - Archives of neurology JO - Arch. Neurol. VL - 56 IS - 1 N2 - The clinical diagnosis of Parkinson disease (PD) is based on the identification of some combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural instability, but few attempts have been made to develop explicit diagnostic criteria. We propose a clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD. Three levels of diagnostic confidence are differentiated: Definite, Probable, and Possible. The diagnoses of Possible and Probable PD are based on clinical criteria alone. Neuropathologic confirmation is required for the diagnosis of Definite PD in patients with the clinical diagnosis of Possible or Probable PD. Criteria for histopathologic confirmation of PD are also presented. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/9923759/full_citation L2 - http://archneur.jamanetwork.com/article.aspx?volume=56&page=33 ER -