TY - JOUR T1 - Antioxidant status in anorexia nervosa. AU - Moyano,D, AU - Sierra,C, AU - Brandi,N, AU - Artuch,R, AU - Mira,A, AU - García-Tornel,S, AU - Vilaseca,M A, PY - 1999/1/30/pubmed PY - 2000/6/20/medline PY - 1999/1/30/entrez SP - 99 EP - 103 JF - The International journal of eating disorders JO - Int J Eat Disord VL - 25 IS - 1 N2 - OBJECTIVE: The study of the antioxidant status in female adolescents (N = 82) with anorexia nervosa, by the measurement of erythrocyte tocopherol concentration, and the determination of activities of the main antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. METHOD: Tocopherol was measured by high-performance liquid chromatography (HPLC) with ultraviolet (UV) detection, and antioxidant enzyme activities by spectrometric methods using a Cobas Fara automated centrifugal analyzer. RESULTS: Tocopherol was significantly decreased in the anorexic patients compared to reference values (p < .02). In 21% of patients, tocopherol levels were below the reference interval. Superoxide dismutase activity was significantly decreased (p < .0001), while catalase activity was increased (p < .0001). The activity of the glutathione system enzymes did not show significant differences between patients and controls. DISCUSSION: The deficient concentration of erythrocyte tocopherol together with the altered antioxidant enzyme activities suggest a certain degree of oxidative damage in anorexia nervosa owing to both factors deficient micronutrient intake and oxidative stress. SN - 0276-3478 UR - https://www.unboundmedicine.com/medline/citation/9924658/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0276-3478&amp;date=1999&amp;volume=25&amp;issue=1&amp;spage=99 DB - PRIME DP - Unbound Medicine ER -