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Unbound Medicine.
(Auton Neurosci[TA])
2,081 results
  • Functional atropine sensitive purinergic responses in the healthy rat bladder. [Journal Article]
    Auton Neurosci. 2020 Jun 09; 227:102693.Stenqvist J, Carlsson T, … Aronsson P
  • While acetylcholine is regarded to be the main directly contractile transmitter substance in the urinary bladder, interactions with other transmitters likely occur. Presently, the interplay between purinergic and cholinergic signalling was investigated to unravel the involvement of the urothelium and efferent neurons in the functionally important purinergically evoked release of acetylcholine in …
  • Management of neurogenic orthostatic hypotension in the heart failure patient. [Review]
    Auton Neurosci. 2020 Jun 06; 227:102691.Dixon DD, Muldowney JAS
  • Neurogenic orthostatic hypotension (nOH) is a common comorbidity in patients with neurodegenerative diseases. It is associated with an increased risk of falls, incident cardiovascular disease, and all-cause mortality. There are over 5 million individuals in the U.S. with heart failure (HF) with an associated 50% mortality rate at 5 years. The prevalence of nOH and HF increase with age and, as the…
  • Psychological correlates of patients with postural orthostatic tachycardia syndrome (POTS). [Journal Article]
    Auton Neurosci. 2020 Jun 06; 227:102690.Fisher CJ, Katzan I, … Wilson R
  • Psychological symptoms are frequently reported in patients with Postural Orthostatic Tachycardia Syndrome (POTS); however, the nature of these symptoms is not well understood. The current study described baseline psychological symptoms in patients with POTS, and examined associations between psychological and self-report autonomic symptoms. Participants reported mild anxiety symptoms, moderate de…
  • Attention and executive function are impaired during active standing in postural tachycardia syndrome. [Journal Article]
    Auton Neurosci. 2020 Jun 06; 227:102692.Miller AJ, Sheehan T, … Arnold AC
  • Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance associated with cognitive dysfunction. We hypothesized executive function and attention is impaired in POTS during active standing. Eighty-seven POTS participants and 39 healthy controls of similar age, sex, and education level completed executive function (Stroop word-color) and attention (CogState Identification) …
  • In vivo paracrine effects of ATP-induced urothelial acetylcholine in the rat urinary bladder. [Journal Article]
    Auton Neurosci. 2020 May 23; 227:102689.Stenqvist J, Aronsson P, … Tobin G
  • Mechanical stretch of the urothelium induces the release of ATP that activates bladder afferent nerves. In the rat urinary bladder, ATP is also a contractile co-transmitter in the parasympathetic innervation. In isolated preparations, ATP evokes a urothelial release of acetylcholine that substantially contributes to ATP-evoked contractile responses. Currently we aimed to further examine the inter…
  • Selective abolition of Mayer waves in conscious endotoxemic rats. [Journal Article]
    Auton Neurosci. 2020 Jul; 226:102673.Julien C, Chapuis B, Barrès C
  • The relation between vascular sympathetic tone and the amplitude of arterial pressure (AP) Mayer waves was examined by analyzing 60-min recordings of AP and renal sympathetic nerve activity (RSNA) obtained in conscious rats before and after lipopolysaccharide administration, which results in strong sympathoexcitation. Mayer waves completely disappeared together with accompanying oscillations of R…
  • Involuntary emotional expression disorder in postural tachycardia syndrome. [Journal Article]
    Auton Neurosci. 2020 Jul; 226:102660.Khurana RK
  • CONCLUSIONS: The study demonstrated frequent occurrence of latent IEED in PoTS and NMH and overt IEED in PoTS without "structural" involvement. HUT was a specific trigger for overt IEED in PoTS. Depression was co-morbid with PoTS. Neurohumoral and cerebral blood flow changes in supine position along with reduced gray matter volume in the insula and cingulate gyrus may underlie susceptibility to IEED. During HUT, cerebral hypoperfusion, rising epinephrine levels, and augmented autonomic arousal provide underpinnings for overt IEED. Clinicians should recognize this entity and counsel PoTS patients and their families. Limiting the duration of orthostatic stress may reduce morbidity.
  • Cardiovagal baroreflex gain relates to sensory loss after spinal cord injury. [Journal Article]
    Auton Neurosci. 2020 Jul; 226:102667.Draghici AE, Taylor JA
  • Spinal cord injury (SCI) leads to autonomic nervous system damage, resulting in loss of sympathetic control to the vasculature and the heart proportional to injury level. Given maintained cardiac parasympathetic control, we hypothesized that SCI demonstrates a compensatory, higher baroreflex gain compared to able-bodied that relates to injury level (neurological and/or sensory). We compared baror…
  • Treatment induced neuropathy of diabetes. [Review]
    Auton Neurosci. 2020 Jul; 226:102668.Gibbons CH
  • CONCLUSIONS: TIND is more common than previously suspected. The number of cases reported over the past 10 years is much greater than historical literature predicted. Increased attention to target glucose control as a physician metric could suggest a possible explanation for the increased in TIND cases reported in recent years. At present, supportive care is the only recommended treatment. Future research is necessary to define the underlying mechanism, prevent development and to guide treatment recommendations.
  • Central sensory-motor crosstalk in the neural gut-brain axis. [Journal Article]
    Auton Neurosci. 2020 Feb 15; 225:102656.Parker CG, Dailey MJ, … Davis EA
  • The neural gut-brain axis consists of viscerosensory and autonomic motor neurons innervating the gastrointestinal (GI) tract. Sensory neurons transmit nutrient-related and non-nutrient-related information to the brain, while motor neurons regulate GI motility and secretion. Previous research provides an incomplete picture of the brain nuclei that are directly connected with the neural gut-brain a…
  • Serotonin and substance P: Synergy or competition in the control of breathing. [Journal Article]
    Auton Neurosci. 2020 Feb 26; 225:102658.Szereda-Przestaszewska M, Kaczyńska K
  • Numerous neurotransmitters identified in the central nervous system play role in ventilatory control. This mini-review focuses on the respiratory effects of two neurotransmitters: serotonin (5-HT) and substance P (SP). We discuss their co-localization in medullary raphe nuclei, expression of proper receptors within the specific regions of respiratory related structures and contribution to respira…
  • Cardiovascular autonomic neuropathy: A silent killer with long reach. [Review]
    Auton Neurosci. 2020 Feb 11; 225:102646.Ang L, Dillon B, … Pop-Busui R
  • Cardiovascular autonomic neuropathy (CAN) is a common and deadly complication of diabetes mellitus, which is frequently overlooked in clinical practice due to its characteristic subtle presentation earlier in disease. Yet, timely detection of CAN may help implementation of tailored interventions to prevent its progression and mitigate the risk of associated complications, including cardiovascular…
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