Metronidazole, a widely used antimicrobial agent, has been associated with rare neuropsychiatric adverse effects, including antibiotic-induced mania (antibiomania). We report the case of a 46-year-old woman with a history of bipolar disorder type I, previously triggered by antidepressant treatment, who presented with an acute onset of a manic episode with psychotic features following prolonged metronidazole treatment. The patient had remained euthymic and medication-free for approximately nine years prior to this episode. Metronidazole was discontinued upon admission, and appropriate psychiatric treatment was initiated. Manic and psychotic symptoms resolved completely within three days, supporting a probable causal association. This case highlights the potential of metronidazole to induce manic episodes, particularly in individuals with a predisposition to mood disorders, and aims to discuss the possible underlying mechanisms through which metronidazole may contribute to the development of mania.

The aim of this paper is to contribute to the increased understanding of research methods on meditation as a tool for preventing and improving mental health by addressing the key challenges that research faces. Different definitions of meditation have been analyzed, and the complexity of the phenomenon, as well as the problems in conceptualization, have been highlighted. It has been emphasized that comparing the results of research is complicated by the fact that meditation encompasses a wide range of practices that differ in techniques, goals, and expected outcomes. A solution to this problem is the operationalization of the type of meditation being investigated and the standardization of protocols. In addition to this, meditators represent a diverse group of individuals who differ in experience, motivation, and characteristics. Therefore, it is essential to track the characteristics of the participants closely and, when conducting quantitative research, stratify the sample according to relevant characteristics. Repeated measurements do not always yield the same results, which is attributed to numerous methodological shortcomings and a lack of a theoretical framework. The successful outcomes of meditation are often determined in various ways, so it is necessary to define measurable outcomes that are specific to the research goals. Given the difficulty of quantifying the subjective experiences resulting from meditation practice, it is beneficial to combine qualitative and quantitative measurements. Due to the complexity of the meditation phenomenon, research should be interdisciplinary, incorporating knowledge and insights from psychology, philosophy, anthropology, neuroscience, biology, sociology, and comparative studies of cultures and religions. More high-quality, qualitative, and interdisciplinary research is needed to understand better the process of meditation and its impact on mental processes, personality, and behavior, and subsequently to improve its application in the field of mental health.