- Drugs and Lactation Database (LactMed): Acetaminophen [BOOK]Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
- Acetaminophen is a good choice for analgesia, and fever reduction in nursing mothers. Amounts in milk are much less than doses usually given to infants. Adverse effects in breastfed infants appear to be rare.
- Priapism, an emerging complication in β-thalassemia intermedia patients. [Case Reports]
- The increase in survival rate of β-thalassemia (β-thal) patients allowed for the appearance and manifestation of several complications in almost every organ system. Priapism in β-thal patients is rarely reported in the literature. We herein report and investigate the occurrence of two cases of priapism in two young patients with β-thal intermedia (β-TI). The potential mechanisms are due to either…
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- A case of levocetirizine-induced fixed drug eruption and cross-reaction with piperazine derivatives. [Case Reports]
- Fixed drug eruption is an uncommon adverse drug reaction caused by delayed cell-mediated hypersensitivity. Levocetirizine is an active (R)-enatiomer of cetirizine and there have been a few reports of fixed drug eruption related to these antihistamines. We experienced a case of levocetirizine-induced fixed drug eruption and cross-reaction with other piperazine derivatives confirmed by patch test. …
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- ["Of snakes and crocodiles": central side effects of nose drops and facts about rhinitis medicamentosa]. [Journal Article]Kinderkrankenschwester. 2011 Oct; 30(10):406-8.K
- Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry. [Journal Article]J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Dec 15; 877(32):4071-8.JC
- A highly efficient, selective and specific method for simultaneous quantitation of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap-tandem mass spectrometry coupled with electro spray ionization (LC-ESI-ion trap-tandem MS) has been validated and successfully applied to a clinical pharmacokinetic study. Both targeted compounds together with the internal standard (…
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- Diurnal variation of prescribing pattern of primary care doctors in Bahrain. [Journal Article]J Eval Clin Pract. 2007 Feb; 13(1):25-30.JE
- CONCLUSIONS: A significant diurnal variation in prescribing, and polypharmacy practice were related to the training background of the doctors. This quantitative study provides the baseline data for monitoring primary care prescribing practices in Bahrain. To further evaluate the underlying factors that influence drug use indicators, a qualitative study is needed.
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- Treatment of the common cold. [Randomized Controlled Trial]
- CONCLUSIONS: Dayquil/Nyquil are as effective as Actifed DM plus paracetamol in controlling the symptoms and signs of the common cold, but have fewer adverse effects. The quality of life assessed during the use of the drugs was significantly higher in the Dayquil/Nyquil group, and according to the patients, they prefered Dayquil/Nyquil more than Actifed DM plus paracetamol.
- Kinetic spectrophotometric methods for the quantitation of triprolidine in bulk and in drug formulations. [Journal Article]
- A kinetic method for the accurate and sensitive determination of triprolidine has been described. The method is based on the alkaline oxidation of triprolidine with KMnO(4). At a fixed time of 20 min, the formed manganate ion is spectrophotometrically measured at 612 nm. The concentration of triprolidine is calculated using the calibration equation for the fixed time method. Beer's law was obeyed…
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- ["Of snakes and crocodiles". Central side effects caused by nose drops]. [Case Reports]HNO. 1998 Mar; 46(3):276-80.HNO
- [A double-blind, placebo-controlled study on the efficacy of Rinasek in symptomatic treatment of seasonal and non-seasonal rhinitis]. [Controlled Clinical Trial]Med Pregl. 1995; 48(7-8):255-9.MP
- In order to assess the efficacy of Rinasek in symptomatic treatment of seasonal and nonseasonal rhinitis, 40 ambulatory otorhinolaryngologic patients were multicentrically examined in a placebo controlled double-blind study. Clinical and other findings show that the drug worked excellent in 46.6%, well in 13.3%, weak in 13.3% and in 10% of patients it had no effects. Consequently, Rinasek worked …
- The influence of diuretics on the excretion and metabolism of doping agents: Part VI. Pseudoephedrine. [Controlled Clinical Trial]
- A capillary gas chromatographic method with nitrogen specific detection is presented for measuring pseudoephedrine and its major metabolite norpseudoephedrine in urine after derivatization with trifluoroacetic anhydride. After the oral intake of 49.2 mg pseudoephedrine (ACTIFED) the active substance is nearly quantitatively excreted in urine over a 48 hr period. From 1 to 7 percent is metabolized…
- Use of drugs by children. [Journal Article]
- To obtain information on the use of prescribed and non-prescribed drugs in the general population of children 1590 children were surveyed in 1984-5 by weekly questionnaires filled out by parents. Drugs were taken in 13% of the 26 weeks studied and on 9% of the 182 days. Use in the summer and winter was similar. More than half (56%) of all drugs were taken on Saturdays and Sundays. Boys took drugs…
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- The simultaneous assay of triprolidine, pseudoephedrine and dextromethorphan in combined preparations by derivative-difference spectrophotometry. [Journal Article]J Pharm Biomed Anal. 1988; 6(5):449-60.JP
- Difference spectrophotometric procedures are described for the assay of triprolidine hydrochloride, dextromethorphan hydrobromide and pseudoephedrine hydrochloride in Actifed preparations. Triprolidine is assayed by the measurement of the difference absorbance at 301 nm between equimolar solutions of the sample extract in 0.1 M sulphuric acid and 0.1 M sodium hydroxide in ethanol (20% v/v). Dextr…
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- Management of middle-ear effusions in children. [Clinical Trial]
- A double-blind placebo controlled trial of Mucodyne (carbocisteine, Berk Pharmaceuticals), Actifed (triprolidine HC1 and pseudoephedrine HC1, Wellcome) and combined Mucodyne and Actifed in the treatment of middle-ear effusions is reported. The trial was undertaken to assess whether either preparation, alone or in combination, would reduce the number of children requiring surgical treatment for th…
- Visual hallucinations in children receiving decongestants. [Letter]Br Med J (Clin Res Ed). 1984 Jun 23; 288(6434):1912-3.BM
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- Visual hallucinations in children receiving decongestants. [Case Reports]
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- Hallucinations in a child after drinking triprolidine/pseudoephedrine linctus. [Case Reports]Lancet. 1984 May 26; 1(8387):1180.Lct
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- Visual hallucinations in children receiving decongestants. [Case Reports]
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- Cariogenic potential of liquid medications in rats. [Journal Article]
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- [Rhinitis therapy. Experiences with triprolidine hydrochloride/pseudoephedrin hydrochloride, a decongestive and antiallergic therapeutic agent]. [Journal Article]Fortschr Med. 1983 Mar 24; 101(11):494-6.FM
- 63 patients were treated with the combination of pseudoephedrine hydrochloride and triprolidine hydrochloride (Actifed). Indications were infectious, allergic and vasomotoric rhinitis. The 63 patients divided in 32 children in the age of 2 to 12 years and 31 adults in the age of 14 to 56 years. The daily dose range depending on age was 90.0 to 180.0 mg pseudoephedrine hydrochloride and 3.75 to 7.…
- A suspected case of codeine-induced erythema multiforme. [Case Reports]Drug Intell Clin Pharm. 1983 Feb; 17(2):128-30.DI
- Erythema multiforme usually presents as an acute inflammatory reaction involving the skin and mucous membranes. Systemic symptoms and organ involvement also can occur. The disease is associated with many illnesses and drugs. A two-year-old child presented to the Family Practice Center with a probable codeine-induced episode of erythema multiforme. The patient had been treated with Actifed-C Expec…
- Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough. [Randomized Controlled Trial]
- Two hundred and seventeen patients between 6 and 12 years of age suffering from acute cough took part in a randomized, single-blind study comparing 'Pholcolix' and 'Actifed' Compound. No significant difference in efficacy was demonstrated but analysis of palatability components (taste, smell, aftertaste and feeling in the mouth) showed numerical superiority for 'Pholcolix' for all parameters, wit…
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- Middle ear effusion in children: a report of treatment in 500 cases. [Journal Article]
- Records were studied of 500 children younger than 9 years of age with middle ear effusion who had received one of three treatment strategies: (1) administration of medication, including decongestants, antihistamines or antibiotics (or a combination), (2) administration of medication for a limited time and then surgical therapy if effusion did not resolve or (3) myringotomy done immediately with i…
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- Paranoid psychosis after abuse of Actifed. [Case Reports]
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- Daytime enuresis. [Letter]Br J Psychiatry. 1982 Mar; 140:325.BJ
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- A double-blind controlled evaluation of Actifed and its individual constituents in allergic rhinitis. [Randomized Controlled Trial]
- Pseudoephedrine and triprolidine, administered every 6 hours as a combination, made separate and distinct contributions to the treatment of allergic rhinitis. Furthermore, the combination was perceived by the patients as being clinically superior to either of its components or placebo.
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