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7,113 results
  • Determination of levodopa by chromatography-based methods in biological samples: a review. [Review]
    Anal Sci. 2022 Jun 17 [Online ahead of print]Jiang R, Yang J, … Zhao Z
  • Levodopa (L-DOPA) is the most effective drug for Parkinson's disease; however, various side effects occur during therapy. L-DOPA metabolites and the high cumulative dose of L-DOPA were responsible for its side effects. It is necessary to monitor the concentration of L-DOPA and its metabolites for individualized therapy. This review focuses on L-DOPA analysis by chromatography-based methods in bio…
  • Perioperative Management of a Patient with Secreting Paraganglioma Undergoing Cesarean Section. [Case Reports]
    Case Rep Anesthesiol. 2022; 2022:9065324.Bettencourt AR, Alves C
  • Paraganglioma is a catecholamine-secreting tumor (CST) in extra-adrenal autonomic ganglia and a rare cause of hypertension during pregnancy. If not properly treated, it can lead to disastrous outcomes for both the mother and fetus. This report describes the successful anesthetic management of a paraganglioma diagnosed during pregnancy. A pregnant woman, with 32 weeks of gestational age, presented…
  • Fabrication of a sensitive sensor for electrochemical detection of diltiazem in presence of methyldopa. [Journal Article]
    Chemosphere. 2022 Jun; 297:134170.Imani R, Shabani-Nooshabadi M, Ziaie N
  • Diltiazem (DTZ) is one of the most important drugs in blood pressure that is used to treat cardiovascular diseases. With this overuse of this drug and its use for suicide, swelling and neck cramps and fever has made it important to measure it. So, this paper will give an account of modification of carbon paste electrode with the ternary-nanocomposite including reduced-graphene oxide (rGO), cadmiu…
  • Antihypertensive Medications for Severe Hypertension in Pregnancy: A Systematic Review and Meta-Analysis. [Review]
    Healthcare (Basel). 2022 Feb 09; 10(2)Awaludin A, Rahayu C, … Zakiyah N
  • CONCLUSIONS: Several drugs can be used to treat severe hypertension in pregnancy, including oral/sublingual nifedipine, IV/oral labetalol, oral methyldopa, IV hydralazine, IV dihydralazine, IV ketanserin, IV nicardipine, IV urapidil, and IV diazoxide. In addition, nifedipine may be preferred as the first-line agent. There was no difference in the risk of maternal hypotension, maternal and fetal outcomes, and adverse effects between the drugs, except for adverse effects in IV dihydralazine and IV ketanserin.
  • Fatal pulmonary oedema associated with severe pre-eclampsia: challenges and lessons. [Case Reports]
    Cardiovasc J Afr. 2022 Feb 17; 33:1-5.Ngene NC, Moodley J
  • Pre-eclampsia complicated by pulmonary oedema, severe hypertension, tachycardia and desaturation is a devastating condition. A comprehensive understanding of the aetiopathogenesis during such an emergency is challenging in the absence of functional and responsive point-of-care imaging, and laboratory and other critical-care services. An unbooked 26-year-old gravida 3 para 1+1 presented to a prima…
  • In Utero Exposure to Antihypertensive Medication during the First Trimester: Is the Risk Worth Taking? [Review]
    Acta Med Acad. 2021 Dec; 50(3):372-381.Papadopoulou Z, Tsialiou TM, … Papamitsou T
  • The aim of this study is to evaluate and present the evidence so far, regarding fetal outcomes after in utero exposure to antihypertensive medication. Hypertensive disorders during pregnancy constitute a significant risk factor for maternal and fetal outcomes, necessitating antihypertensive treatment. However, current data concerning the safety of in utero exposure to antihypertensive medication …
  • Alpha-Methyldopa May Attenuate Insulin Demand in Women with Gestational Diabetes Treated with Betamethasone. [Journal Article]
    Healthcare (Basel). 2022 Jan 10; 10(1)Kakoulidis I, Thomopoulos C, … Koukkou E
  • Gestational diabetes mellitus (GDM) is associated with hypertensive disorders in pregnancy. Alpha-methyl-DOPA (αMD) is a commonly used medication for hypertension in pregnant women. This medication may be associated with alteration in insulin resistance and glucose homeostasis. The aim of the present study was to investigate in 152 pregnant women whether the demands of exogenous insulin in glucoc…
  • Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations. [Journal Article]
    Nat Commun. 2021 12 02; 12(1):7026.Iskhakova L, Rappel P, … Bergman H
  • Βeta oscillatory activity (human: 13-35 Hz; primate: 8-24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson's disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of hea…
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