- Is There any Relationship Between Myocardial Repolarization Parameters and the Frequency of Ventricular Premature Contractions? [Journal Article]
- ABArq Bras Cardiol 2018; 110(6):534-541
- CONCLUSIONS: Tp-e interval and Tp-e/QTc ratio increased in patients with high VPC number. Our study showed that VPCs may have a negative effect on myocardial repolarization. This interaction may lead to an increased risk of malignant arrhythmias.
- Exertional heat illness: knowledge and behavior among construction workers. [Journal Article]
- ESEnviron Sci Pollut Res Int 2018 Sep 17
- Construction workers are considered one of the most vulnerable health group workers. Exertional heat illness (EHI) is a well-recognized health hazard that causes significant sickness and death. The p...
Construction workers are considered one of the most vulnerable health group workers. Exertional heat illness (EHI) is a well-recognized health hazard that causes significant sickness and death. The purpose of this study was to assess construction workers' environment and hydration status and to evaluate the effect of health education program on workers. An interventional study was conducted on 89 construction workers in Port Said City. Assessments of workplace environment and workers' hydration status were done by using workplace evaluation checklist, wet-bulb globe temperature, urine specific gravity, and urine color chart. A pre-post-test design was used in the evaluation of workers' knowledge and behavior regarding EHI. A health education program was conducted to improve workers' knowledge and behavior; then, evaluation was done after 1 month. The most reported symptoms of heat illness were sweating (100.0%), dizziness (98.0%), and muscle pain (82.0%). Most workers showed signs of minimal dehydration (78.7%). There was a significant improvement in workers' knowledge about EHI and behavioral action for prevention after health education. Construction workers are at high risk of exposure to EHI which raised the attention to provide educational programs which can guide workers to follow healthy behaviors and prevent EHI.
- Dabrafenib and Trametinib Treatment for Erdheim-Chester Disease With Brain Stem Involvement. [Journal Article]
- MCMayo Clin Proc Innov Qual Outcomes 2018; 2(3):303-308
- Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by infiltration of organs by CD68+ and CD1a- lipid-laden histiocytes, including the central nervous sys...
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by infiltration of organs by CD68+ and CD1a- lipid-laden histiocytes, including the central nervous system in more than a third of patients. Molecular analysis of ECD samples has demonstrated the prevalence of BRAF V600E mutations as high as 54%. Recently, vemurafenib became the only Food and Drug Administration-approved treatment for patients with ECD who carry the BRAF V600E mutation. However, dabrafenib has been suggested to have greater brain distribution. We describe a 44-year-old female patient treated from August of 2015 through November 2017. She presented with a 2-year history of light-headedness, fatigue, and vertigo. She was moderately dysmetric, diffusely hyperreflexic, and dysarthric in the bilateral upper and lower extremities. Her gait was wide-based. She had dysarthria and nystagmus on horizontal gaze bilaterally. Magnetic resonance imaging showed an extensive area of increased T2/fluid-attenuated inversion recovery signal in the brain stem, enhancement in the pons and midbrain, and thickening of the pituitary stalk. Positron emission tomography/computed tomography (PET/CT) and whole-body technetium Tc99m bone scintigraphy showed intense symmetrical radiotracer uptake in the distal femur and tibia bilaterally, which was biopsied. Immunohistochemistry was negative for BRAF V600E, but genomic sequencing revealed the mutation. The patient received combination therapy with dabrafenib and trametinib. Her nystagmus, dysarthria, dysmetria, and gait improved remarkably. Subsequent PET/CT and magnetic resonance imaging showed complete resolution of all radiographic evidence of disease. In this case report, we demonstrate the success of a combination therapy with dabrafenib and trametinib.
- Patient-Reported and Performance Outcomes Significantly Improved in Elderly Patients with Vestibular Impairment following Rehabilitation: A Retrospective Study. [Journal Article]
- JAJ Aging Res 2018; 2018:5093501
- CONCLUSIONS: The functional outcome measures reported, including TUG, gait speed, and DHI, reflect statistically significant improvements in elderly patients after vestibular rehabilitation; the DHI improvements are clinically relevant.
- A randomized single-dose safety, pharmacokinetics, food effect and effect on thorough QT/QTc of Chinfloxacin in healthy Chinese Volunteers. [Journal Article]
- AAAntimicrob Agents Chemother 2018 Sep 17
- Chinfloxacin hydrochloride is a novel tricyclic fluorinated quinolone in development for treatment of conventional and biothreat infections. This first-in-human randomized study in Chinese healthy su...
Chinfloxacin hydrochloride is a novel tricyclic fluorinated quinolone in development for treatment of conventional and biothreat infections. This first-in-human randomized study in Chinese healthy subjects was divided into 5 parts. Part A was a single ascending dose study to assess safety and tolerability of chinfloxacin. The single dose pharmacokinetic study, food effect study and a multiple dose pharmacokinetics study was conducted in Part B, Part C and Part D, respectively. Part E was a randomized, placebo- and positive-controlled single-dose, crossover study to evaluate the effect of chinfloxacin on thorough electrocardiographic QT/QTc interval. The results suggest that single and multiple oral administration of chinfloxacin were well tolerated. The observed adverse events (AEs) were dizziness, nausea, weakness, photosensitive dermatitis and increased frequency of defecation. All AEs were mild and were resolved spontaneously without any treatment. The time to Cmax (Tmax) was about 2 h and T1/2 was 14-16 h. Food slightly affected the drug's rate and extent of absorption, increasing the Tmax from 1.60 to 2.59 h and reducing the Cmax by 13.6% and AUC by 8.95%, respectively. Chinfloxacin 400 mg had no effect on prolongation of QT/QTc intervals. Although chinfloxacin 600 mg caused mild effect on prolongation of QT/QTc interval, the effect was less pronounced than that of the positive control, moxifloxacin 400 mg. The pharmacokinetics and safety profiles of chinfloxacin in healthy Chinese volunteers support its once-daily dosing in future clinical investigations. (This study has been registered at ChiCTR.org.cn. Identifier of Part A to Part D: ChiCTR-TRC-10001619; Identifier of the Part E: ChiCTR1800015906.).
- Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence. [Journal Article]
- AJAm J Otolaryngol 2018 Sep 12
- CONCLUSIONS: It is reported that BPPV is a common complication in patients surgically managed for SSCD. Posterior semicircular canal BPPV is reported most often, with a couple of cases of lateral semicircular canal BPPV also reported. As far as we are aware, the current case represents the first report of anterior semicircular canal BPPV in this type of patient.
- Comparison of intraperitoneal versus intravenous dexamethasone on postoperative nausea and vomiting after gynecological laparoscopy: a randomized clinical trial. [Journal Article]
- KJKorean J Anesthesiol 2018 Sep 18
- CONCLUSIONS: Intraperitoneal dexamethasone in a dose of 8 mg at the end of gynecological laparoscopy reduces the incidence of postoperative nausea.
- Fear of blood draw is associated with inflated expectations of faint and prefaint reactions to blood donation. [Journal Article]
- TTransfusion 2018 Sep 17
- CONCLUSIONS: The general public has inflated expectations of the risk for faint and prefaint reactions to blood donation, suggesting that efforts to educate prospective donors with accurate information may help to reduce this relatively common concern.
- Benign Paroxysmal Positional Vertigo in Children. [Journal Article]
- COClin Otolaryngol 2018 Sep 16
- CONCLUSIONS: BPPV can be diagnosed accurately by taking a detailed medical history and by use of positional testing. BPPV in children can be successfully identified and treated. This article is protected by copyright. All rights reserved.
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- Semicircular Canal Dehiscence Syndrome and Vestibular Dysfunction Disqualify a Military Student Pilot. [Journal Article]
- AMAerosp Med Hum Perform 2018 Oct 01; 89(10):923-926
- CONCLUSIONS: Spatial disorientation remains one of the deadliest factors related to aircraft mishaps every year. In this case, an abnormal presentation of airsickness that prompted further evaluation may have prevented a dangerous situation in the air. In standard airsickness, the goal is to keep the pilot flying to expedite adaptation, so this case highlights the importance of distinguishing between normal airsickness and a spatially disorienting medical condition.Dreibelbis JA, Organ BE. Semicircular canal dehiscence syndrome and vestibular dysfunction disqualify a military student pilot. Aerosp Med Hum Perform. 2018; 89(10):923-926.