- Combination pharmacotherapy for the treatment of fibromyalgia in adults. [Review]
- CDCochrane Database Syst Rev 2018 Feb 19; 2:CD010585
- CONCLUSIONS: There are few, large, high-quality trials comparing combination pharmacotherapy with monotherapy for fibromyalgia, consequently limiting evidence to support or refute the use of combination pharmacotherapy for fibromyalgia.
- Progressive Depigmentation in a Patient with Panuveitis and Meningitis. [Journal Article]
- SASkin Appendage Disord 2018; 4(1):12-14
- Awake Craniotomy for the Treatment of a Cortical Pseudoaneurysm in a Pregnant Patient. [Journal Article]
- CCureus 2017 Dec 07; 9(12):e1921
- Neurosurgical pathologies presenting during pregnancy are uncommon. If present, the situation creates a unique diagnostic, observational, and therapeutic challenge as both lives are placed at potenti...
Neurosurgical pathologies presenting during pregnancy are uncommon. If present, the situation creates a unique diagnostic, observational, and therapeutic challenge as both lives are placed at potential risk. Surgical procedures during pregnancy are approached carefully as physiological stressors associated with surgery and anesthesia may cause fetal or maternal compromise. We present the only known case of a pseudoaneurysm treated with an awake craniotomy, allowing us to abate the risks associated with general anesthesia in pregnancy. A female suffered a superficially penetrating gunshot wound to the head for which she underwent a craniotomy with complete neurological recovery. She had complaints of intermittent headaches, dizziness, and tingling of her hands five months thereafter. The cerebral angiogram demonstrated an 8 mm pseudoaneurysm under her craniotomy site. A surgical repair of this aneurysm was undertaken in the 23rd week of pregnancy via an awake craniotomy with regional scalp block. The aneurysm was resected without complication, and the patient tolerated the procedure without neurological deficit during or subsequent to the operation. Cerebrovascular pathology in pregnant patients remains a difficult situation that poses challenges associated with the pathology itself as well as the anesthetic implications inherent with operative management. The neurosurgical literature demonstrates that surgical management of cerebrovascular pathology is well-tolerated in pregnancy, and our case further demonstrates the capability of utilizing an awake craniotomy for the treatment of this type of lesion without causing a residual deficit.
- Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. [Journal Article]
- ETExp Ther Med 2018; 15(3):2321-2326
- The purpose of this study was to investigate the curative effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). Fifty BPPV patients diagnosed in the ENT Department of Anz...
The purpose of this study was to investigate the curative effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). Fifty BPPV patients diagnosed in the ENT Department of Anzhen Hospital from October 2015 to December 2016 were randomly selected as the treatment group, and treated with 0.25 µg 1α-hydroxyvitamin D3 once per day, in addition to the routine diagnosis and treatment. Moreover, 50 BPPV patients in the same period were selected as the control group, and received the routine diagnosis and treatment. The detection results of bone mineral density (BMD) t-value, vitamin D3 and bone metabolic markers before and after treatment were compared, and statistical analysis was performed on the results. There were no differences in the general data between treatment group and control group. There were no statistically significant differences in the BMD and age distribution of males and females between treatment group and control group (P>0.05). The BMD of male BPPV patients in each age group in the treatment group was significantly increased after treatment, and the difference was statistically significant (P<0.05). Although the BMD of male BPPV patients in each age group in control group was somewhat increased after treatment, the difference was not statistically significant (P>0.05). The BMD of female BPPV patients in each age group in treatment group was increased after treatment, and the difference was statistically significant (P<0.05). Similarly, although the BMD of female BPPV patients in each age group in control group was somewhat increased after treatment, the difference was not statistically significant (P>0.05). The average BMD of female BPPV patients in each age group was significantly lower than that of male patients, and the difference was statistically significant (P<0.05) (Table II). The BMD t-value of patients in treatment group showed a decreasing trend with the increase of age (Fig. 1). The levels of 25-hydroxyvitamin D3 and bone metabolic markers in treatment group were significantly improved compared with those before treatment (P<0.05). Multivariate Logistic regression analysis was performed to identify whether the treatment of BPPV was effective or not as a dependent variable, and six items, including the sex (female), hypertension, diabetes mellitus, age (>50 years), 25-hydroxyvitamin D3 and osteopenia/osteoporosis, as the independent variables, and the results suggested that the level of 25-hydroxyvitamin D3 and osteopenia/osteoporosis are the clinical features of whether the BPPV treatment is effective (P<0.05). The results showed that the treatment of BPPV with 1α-hydroxyvitamin D3 can effectively improve the symptoms of patients, and the level of vitamin D3 and the occurrence of osteopenia/osteoporosis are the clinical indexes of whether the BPPV treatment is effective.
- A Review on Central Nervous System Effects of Gastrodin. [Review]
- FPFront Pharmacol 2018; 9:24
- Rhizoma Gastrodiae(also known asTian ma), the dried rhizome ofGastrodia elataBlume, is a famous Chinese herb that has been traditionally used for the treatment of headache, dizzin...
Rhizoma Gastrodiae(also known asTian ma), the dried rhizome ofGastrodia elataBlume, is a famous Chinese herb that has been traditionally used for the treatment of headache, dizziness, spasm, epilepsy, stoke, amnesia and other disorders for centuries. Gastrodin, a phenolic glycoside, is the main bioactive constituent ofRhizoma Gastrodiae. Since identified in 1978, gastrodin has been extensively investigated on its pharmacological properties. In this article, we reviewed the central nervous system (CNS) effects of gastrodin in preclinical models of CNS disorders including epilepsy, Alzheimer's disease, Parkinson's disease, affective disorders, cerebral ischemia/reperfusion, cognitive impairment as well as the underlying mechanisms involved and, where possible, clinical data that support the pharmacological activities. The sources and pharmacokinetics of gastrodin were also reviewed here. As a result, gastrodin possesses a broad range of beneficial effects on the above-mentioned CNS diseases, and the mechanisms of actions include modulating neurotransmitters, antioxidative, anti-inflammatory, suppressing microglial activation, regulating mitochondrial cascades, up-regulating neurotrophins, etc. However, more detailed clinical trials are still in need for positioning it in the treatment of neurological disorders.
- Intratympanic Injections of Dexamethasone in Delayed Endolymphatic Hydrops: A Prospective Clinical Study. [Journal Article]
- OJORL J Otorhinolaryngol Relat Spec 2018 Feb 16; 80(1):19-27
- CONCLUSIONS: ITD is proven to be a valuable and promising alternative modality for the management of ipsilateral DEH.
- Hobnail (Retiform-Dabska) Hemangioendothelioma located in Jejunum. [Journal Article]
- DEDig Endosc 2018 Feb 17
- A 27-year-old man referred to our department with a 1-month history of intermittent melena and dizziness. Gastroscopy and colonoscopy did not identify the site of bleeding. Laboratory data showed hem...
A 27-year-old man referred to our department with a 1-month history of intermittent melena and dizziness. Gastroscopy and colonoscopy did not identify the site of bleeding. Laboratory data showed hemoglobin 6.6g/dL. Video capsule endoscopy (CE, Anhon,China) and antegrade double-ballon enteroscopy (DBE, EN450P5, Fujinon, Japan) were carried out and a space occupying lesion in the proximal jejunum was identified (Fig.1). Ink tattooing via DBE was performed to mark the site of the tumor.Then the patient underwent jejunectomy. This article is protected by copyright. All rights reserved.
- Long-term hearing results of stapedotomy: analysis of factors affecting outcome. [Journal Article]
- EAEur Arch Otorhinolaryngol 2018 Feb 16
- CONCLUSIONS: Our series confirms excellent hearing results achieved in stapedotomy surgery, also in long-term follow-up. On the long-term no patient-, disease-, or procedure-related variables were identified as predictors of surgical success.
- Bone Metabolic Markers in the Clinical Assessment of Patients with Superior Semicircular Canal Dehiscence Treated with Middle Fossa Craniotomy. [Journal Article]
- WNWorld Neurosurg 2018 Feb 13
- CONCLUSIONS: Bone metabolic markers may be important in the clinical assessment of SSCD patients and could be potential targets for symptom management.
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- Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine. [Journal Article]
- EEpilepsia 2018 Feb 16
- CONCLUSIONS: Baseline use of CBZ or other major putative VGSC inhibitors did not appear to significantly increase the risk of study exit due to worsening seizure control, or to increase the frequency of side effects when converting to ESL monotherapy. However, bigger improvements in efficacy may be possible in patients converting to ESL monotherapy from an AED regimen that does not include a VGSC inhibitor.