- Sleep in infants and toddlers with Down syndrome compared to typically developing peers: looking beyond snoring. [Journal Article]Sleep Med 2019; 63:88-97SM
- CONCLUSIONS: Overall, significant differences in sleep patterns, problems, and ecology were found between children with DS and controls. Parental presence at settling, not snoring, explained most differences, including over an hour's less 24-hour sleep. Early intervention programmes that promote self-soothing skills could prevent the burden of sleep loss in young children with DS.
- Effect of insomnia after acute ischemic stroke on cerebrovascular reactivity: a prospective clinical study in China. [Journal Article]Sleep Med 2019; 63:82-87SM
- CONCLUSIONS: Insomnia after acute ischemic stroke is an independent risk factor for CVR.
- Psychometric properties of the Kurdish version of Pittsburgh Sleep Quality Index. [Journal Article]Sleep Med 2019; 63:75-81SM
- CONCLUSIONS: The results of this study support the PSQI's validity and reliability. This study offers a foundation for further studies in Kurdish populations.
- Clinical presentation, diagnosis and polysomnographic findings in children with migraine referred to sleep clinics. [Journal Article]Sleep Med 2019; 63:57-63SM
- CONCLUSIONS: Children referred to the sleep clinic who also had migraine, experience various types of sleep complaints. OSA, insomnia, and PLMD were relatively common in this population. Changes in sleep architecture, specifically increased NREM2 and decreased slow wave sleep compared to the control group, were also observed.
- Risk of resistant hypertension associated with restless legs syndrome and periodic limb movements during sleep: a study on 673 treated hypertensive individuals. [Journal Article]Sleep Med 2019; 63:46-56SM
- CONCLUSIONS: In treated hypertensive individuals, frequent RLS combined with PLMS index ≥26/h is associated with higher risk of RHT which suggests that this pathology may be a secondary cause of RHT (eg, obstructive sleep apnoea syndrome and insomnia with short sleep duration) justifying the establishment of effective treatments in this particular subpopulation.
- Sleep and neurocognitive decline in the Hispanic Community Health Study/Study of Latinos. [Journal Article]Alzheimers Dement 2019AD
- CONCLUSIONS: Long sleep duration predicted seven-year cognitive decline.
- Prevalence of insomnia (symptoms) in T2D and association with metabolic parameters and glycemic control: meta-analysis. [Journal Article]J Clin Endocrinol Metab 2019JC
- CONCLUSIONS: The prevalence of insomnia (symptoms) is 39% (95%CI:34-45) in the T2D population and may be associated with deleterious glycemic control.
- [Analgesic and sedative effects of Mongolian medicine Syringa pinnatifolia]. [Journal Article]Zhongguo Zhong Yao Za Zhi 2019; 44(17):3830-3836ZZ
- The peeled root,stem or twig of Syringa pinnatifolia is a representative Mongolian folk medicine with the effects of antidepression and pain relief. It has been used for the treatments of heart tingling,heart palpitations,upset,insomnia and other symptoms. Inspired by Mongolian medical theory and clinical practices,this study evaluated the analgesic effect of S. pinnatifolia ethanol extract(T) th…
The peeled root,stem or twig of Syringa pinnatifolia is a representative Mongolian folk medicine with the effects of antidepression and pain relief. It has been used for the treatments of heart tingling,heart palpitations,upset,insomnia and other symptoms. Inspired by Mongolian medical theory and clinical practices,this study evaluated the analgesic effect of S. pinnatifolia ethanol extract(T) through three analgesic models including acetic acid writhing test,formalin test,and hot plate test,and the sedative effect of T was evaluated by locomotor activity and synergistic sleeping experiments,and furthermore the effects of T on the GABAergic nervous system were investigated by ELISA,immunohistochemistry,Western blot,and PCR methods. The results showed that T can significantly reduce the number of writhing,the time of paw licking and extend the thermal threshold of mice,suggesting the analgesic effect of T.T also can indicate its sedative effect by reducing the number of activities,decreasing latency of sleeping and extending sleeping time of mice. ELISA results showed that T can increase the content of GABA/Glu in rat cortex,hippocampus,and hypothalamus,and the most significant increase in hypothalamus. The immunohistochemistry and Western blot results showed that T can up-regulate the expression of GAD67 protein in hypothalamus,and the PCR results showed that T can up-regulate the expression of GABAA Rα1,α2,α3,α5,β1-3,γ1-3 genes,suggesting a sedative effect through the GABAergic nervous system. In conclusion,this study shed insight into the theoretical basis and clinical application of S. pinnatifolia,and also provides inspiration for subsequent development and application.
- Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice. [Journal Article]Nutrients 2019; 11(10)N
- The bidirectional communication between the gastrointestinal tract and the central nervous system appears to be functionally linked to the intestinal microbiome, namely the microbiome-gut-brain axis (MGBA). Probiotics with health benefits on psychiatric or neurological illnesses are generally called psychobiotics, and some of them may also be able to improve sleep by targeting the MGBA. This stud…
The bidirectional communication between the gastrointestinal tract and the central nervous system appears to be functionally linked to the intestinal microbiome, namely the microbiome-gut-brain axis (MGBA). Probiotics with health benefits on psychiatric or neurological illnesses are generally called psychobiotics, and some of them may also be able to improve sleep by targeting the MGBA. This study aimed to investigate the effects of a psychobiotic strain, Lactobacillus fermentum PS150TM (PS150TM), on sleep improvement by using a pentobarbital-induced sleep mouse model. Compared with the vehicle control group, the oral administration of PS150TM, but not the other L. fermentum strains, significantly decreased the sleep latency and increased the sleep duration of mice, suggesting strain-specific sleep-improving effects of PS150TM. Moreover, the ingestion of diphenhydramine, an antihistamine used to treat insomnia, as a drug control group, only increased the sleep duration of mice. We also found that the sleep-improving effects of PS150TM are time- and dose-dependent. Furthermore, the oral administration of PS150TM could attenuate a caffeine-induced sleep disturbance in mice, and PS150TM appeared to increase the expression of the gene encoding the adenosine 1 receptor in the hypothalamus of mice, as assessed by quantitative real-time polymerase chain reaction. Taken together, our results present a potential application of PS150TM as a dietary supplement for sleep improvement.
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- Efficacy and placebo response of repetitive transcranial magnetic stimulation for primary insomnia. [Journal Article]Sleep Med 2019; 63:9-13SM
- CONCLUSIONS: The rTMS was effective in the treatment of primary insomnia, yet, the placebo effect of sham stimulation was highly significant. This new evidence may alter rTMS regimen for insomnia from a clinical and methodological point of view. Finally, in future research more objective data and multicenter double-blinded controlled studies should be encouraged.