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22,289 results
  • The Impact of Tacrolimus Exposure on Extrarenal Adverse Effects in Adult Renal Transplant Recipients. [Journal Article]
  • BJBr J Clin Pharmacol 2018 Nov 10
  • Campagne O, Mager DE, … Tornatore KM
  • CONCLUSIONS: Several AEs (i.e., diarrhea, dyspepsia, insomnia, and neurologic AE ratio) were associated with tacrolimus dose normalized AUCss,0-12hr , and clearance. Skin changes and acne were associated with dose-normalized CMAX concentrations. To facilitate clinical implementation, a LSS was developed to predict AUCss,0-12hr values using sparse patient data to efficiently assess projected immunosuppressive exposure and potentially minimize AE manifestations.
  • Insomnia and Suicidal Ideation in Non-Affective Psychosis. [Journal Article]
  • SSleep 2018 Nov 08
  • Miller BJ, Parker CB, … McCall WV
  • CONCLUSIONS: Insomnia is associated with suicidal ideation, lifetime suicide attempt, and greater psychopathology in patients with schizophrenia. Our findings suggest that formal assessment of insomnia may be germane to the clinical care of patients with schizophrenia as a marker of suicide risk and symptom severity.
  • Massive idiopathic spontaneous hemothorax complicating anti-N-methyl-d-aspartate receptor encephalitis: A case report. [Journal Article]
  • MMedicine (Baltimore) 2018; 97(45):e13188
  • Wang X, Lai Y, … Che G
  • CONCLUSIONS: In this case, the patient had both anti- NMDAR encephalitis and autoimmune thyroid disease. Based on it, we suspected that the patient subjected to severe autoimmune response and inflammatory reaction, which might explain the pathologic changes of parietal pleura and visceral pleura. We recommend the suspicion of spontaneous hemothorax should be considered when the patients with autoimmune diseases present with hemorrhage-related signs or symptoms.
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