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(PFTs DLCO diffusion capacity increased)
11 results
  • Inhaled Interferon and Diffusion Capacity in Idiopathic Pulmonary Fibrosis (IPF). [Randomized Controlled Trial]
  • SVSarcoidosis Vasc Diffuse Lung Dis 2015; 32(1):37-42
  • Skaria SD, Yang J, … Smaldone GC
  • CONCLUSIONS: DLCO was significantly improved following inhaled (IFN-γ) as treatment for IPF. Our data suggest that previous studies utilizing parenteral IFN-γ may have failed because of the mode of delivery. Future randomized, controlled, phase 3 trials, comparing the difference in PFT behavior (specifically DLCO) longitudinally may be more sensitive to drug effect and serve as a valuable clinical endpoint.
  • Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints. [Journal Article]
  • IJInt J Radiat Biol 2000; 76(4):469-75
  • Marks LB, Fan M, … Anscher M
  • CONCLUSIONS: Regional radiographic changes in CT-defined tissue density or SPECT-defined tissue perfusion are similar in patients with and without RT-induced pulmonary symptoms because these endpoints do not consider the volume of lung affected. RT-induced pulmonary symptoms are better related to post-RT PFT because they are an assessment of whole lung function. Additional studies are necessary to better define models that can predict the degree of radiation-induced changes in whole lung function.
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