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Unbound Medicine.
(acetohydroxamic acid)
473 results
  • Synthesis of Phenols from Aryl Ammonium Salts under Mild Conditions. [Journal Article]
    J Org Chem. 2022 Oct 07; 87(19):12677-12687.Ni P, Yang L, … Ye J
  • A general method for the synthesis of phenols from electron-deficient aryl ammonium salts or heteroaryl ammonium salts under mild conditions was developed. Benzaldehyde oxime, acetohydroxamic acid, and hydroxylamine hydrochloride were investigated as hydroxide surrogates respectively. With these hydroxide surrogates, a series of phenols were prepared in yields of 20-98%.
  • Phenolic Profile and Antioxidant, Anticholinergic, and Antibacterial Properties of Corn Tassel. [Journal Article]
    Plants (Basel). 2022 Jul 22; 11(15)Al-Khayri JM, Yüksel AK, … Dikici E
  • Corn tassel (CT) is a waste part of the corn plant. It is a good co-product and rich in terms of bioactive compounds and phytochemicals. This research tried to show the phenolic profile, antioxidants, anticholinergic activities, and antibacterial properties of CT ethanol extract. The phenolic content analysis of the CT was determined quantitatively by LC-MS/MS, and the antioxidant capacity was me…
  • Recent Efforts in the Discovery of Urease Inhibitor Identifications. [Review]
    Curr Top Med Chem. 2022; 22(2):95-107.Song WQ, Liu ML, … Xiao ZP
  • Urease is an attractive drug target for designing anti-infective agents against pathogens such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past century, hundreds of medicinal chemists focused their efforts on explorations of urease inhibitors. Despite the FDA's approval of acetohydroxamic acid as a urease inhibitor for the treatment of struvite nephrolithiasis an…
  • Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking. [Journal Article]
    Sci Total Environ. 2022 Feb 20; 808:151946.He Y, Zhang X, … Wang J
  • Inhibition of ruminal bacterial urease activity could slow down the decomposition of urea to ammonia, which would lead to a decrease in urea synthesis in the liver and urea-N emission in the urine. In order to find a rumen bacterial urease specific inhibitor that is environmentally friendly, we used the homology model of rumen bacterial urease as the target to screen natural compounds from plants…
  • Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors. [Journal Article]
    ChemMedChem. 2022 01 19; 17(2):e202100618.Liu ML, Li WY, … Zhu HL
  • Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2'-dithiobis(N-(2-flu…
  • Untargeted GC-MS investigation of serum metabolomics of coronary artery disease patients. [Journal Article]
    Saudi J Biol Sci. 2020 Dec; 27(12):3727-3734.Qamar W, Alqahtani S, … Altamimi MA
  • Recent advances in metabolomics provide tools to investigate human metabolome in order to establish new parameters to study different approaches towards diagnostics, diseases and their treatment. The present study focused on the untargeted identification of metabolites in serum of patients with coronary artery disease who were under treatment at the time of sample collection. AUCs (Area Under the…
  • Oral Acidification with l-Methionine as a Noninvasive Treatment for Encrusted Uropathy. [Journal Article]
    J Endourol Case Rep. 2020; 6(3):143-146.Sabiote L, Emiliani E, … Angerri O
  • Background: Encrusted uropathy (EU) is a rare disease caused by urea-splitting bacteria, most commonly Corynebacterium urealyticum, whose incidence is increasing. Standard treatment is based on pathogen-directed antibiotic therapy, urinary diversion, bladder instillations, and surgical resection of urinary calcifications. Case Presentation: We present the case of a 60-year-old man with symptomati…
  • Siderophore-Assisted Dissolution of Iron(III) Hydroxide Oxides from Iron-Rich Fossil Matrices. [Journal Article]
    Chempluschem. 2020 08; 85(8):1747-1753.da Costa J, Cohen DR, … Hand SJ
  • Current paleontological techniques to separate vertebrate fossils from encasing iron-rich cements by chemical means are limited by the low solubility of common iron(III) hydroxide oxides such as hematite and goethite. This study examines novel geochemical extractions capable of selectively dissolving iron(III) hydroxide oxides, in aqueous solutions of pH 9-11, without damaging fossilised bones or…
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