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1,886 results
  • Pharmacological management of severe Cushing's syndrome: the role of etomidate. [Review]
    Ther Adv Endocrinol Metab. 2022; 13:20420188211058583.Pence A, McGrath M, … Raines DE
  • Cushing's syndrome (CS) is an endocrine disease characterized by excessive adrenocortical steroid production. One of the mainstay pharmacological treatments for CS are steroidogenesis enzyme inhibitors, including the antifungal agent ketoconazole along with metyrapone, mitotane, and aminoglutethimide. Recently, osilodrostat was added to this drug class and approved by the US Food and Drug Adminis…
  • Tamsulosin facilitates depressive-like behaviors in mice: Involvement of endogenous glucocorticoids. [Journal Article]
    Brain Res Bull. 2022 01; 178:29-36.Holanda VAD, Oliveira MC, … Gavioli EC
  • The benign prostatic hyperplasia (BPH) is the main source of lower urinary tract symptoms. The BPH is a common age-dependent disease and tamsulosin is an α1-adrenoceptor blocker widely prescribed for BPH. Beyond the common adverse effects of tamsulosin, increased diagnosis of dementia after prescription was observed. Importantly, a clinical study suggested that tamsulosin may exert antidepressant…
  • Molecular mechanisms, immune cell infiltration, and potential drugs for prostate cancer. [Journal Article]
    Cancer Biomark. 2021; 31(1):87-96.Yan Y, Mao X, … Mo Z
  • CONCLUSIONS: AMACR, FOLH1 and NPY may be effective therapeutic targets and specific diagnostic markers for prostate cancer. AMACR, FOLH1, and NPY are also closely associated with immune cell infiltration in prostate cancer. Moreover, aminoglutethimide and resveratrol were found to be the promising drugs for treating prostate cancer. The progression of hormone-sensitive prostate cancer to CRPC may be related to arachidonic acid metabolism, PPAR signaling pathway, AMPK signaling pathway, and other metabolic pathways. SCD and FASN are expected to be the potential therapeutic targets for CRPC.
  • Evaluation of Synthesized Ester or Amide Coumarin Derivatives on Aromatase Inhibitory Activity. [Journal Article]
    Biol Pharm Bull. 2020; 43(8):1179-1187.Yamaguchi Y, Nishizono N, Oda K
  • Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures …
  • Synthetic isoflavones and doping: A novel class of aromatase inhibitors? [Journal Article]
    Drug Test Anal. 2019 Feb; 11(2):208-214.Iannone M, Botrè F, … de la Torre X
  • Anectodical information suggests that flavonoids may be widely used among athletes for their multiple biochemical and pharmacological effects. We have evaluated in vitro the effects of two synthetic isoflavones, methoxyisoflavone and ipriflavone, on the catalytic activity of human aromatase (CYP19), the enzyme catalyzing the conversion of androgens (ie, testosterone or androstenedione) to estroge…
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