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Unbound Medicine.
(cryocrit)
134 results
  • Treatment for hepatitis C virus-associated mixed cryoglobulinaemia. [Review]
    Cochrane Database Syst Rev. 2018 May 07; 5:CD011403.Montero N, Favà A, … Soler MJ
  • CONCLUSIONS: To treat HCV-associated mixed cryoglobulinaemia, it may be beneficial to eliminate HCV infection by using antiviral treatment and to stop the immune response by using rituximab. For skin vasculitis and for some laboratory findings, it may be appropriate to combine antiviral treatment with deletion of B-cell clonal expansions by using of rituximab. The applicability of evidence reviewed here is limited by the absence of any studies with direct-acting antivirals, which are urgently needed to guide therapy.
  • Long-Term Outcomes of Patients With HCV-Associated Cryoglobulinemic Vasculitis After Virologic Cure. [Journal Article]
    Gastroenterology. 2018 08; 155(2):311-315.e6.Bonacci M, Lens S, … Forns X
  • Patients with hepatitis C virus-associated cryoglobulinemic vasculitis (HCV-CV) have high rates of clinical remission after treatment with direct-acting antivirals (DAAs), but circulating cryoglobulins persist, and vascular disorders reappear in some patients shortly after DAA treatment ends. We performed a prospective study to assess the long-term clinical and immune system effects of HCV eradic…
  • Clinical presentation and outcomes of patients with type 1 monoclonal cryoglobulinemia. [Journal Article]
    Am J Hematol. 2017 Jul; 92(7):668-673.Sidana S, Rajkumar SV, … Kumar SK
  • We describe a series of 102 patients diagnosed from January 1, 1990 to December 31, 2015 with Type 1 monoclonal cryoglobulinemia (MoC). Symptoms were seen in 89 (87%) patients, including: cutaneous symptoms in 64 (63%) patients, with purpura (n = 43, 42%) and ulcers/gangrene (n = 35, 34%) being most common; neurological findings in 33 (32%) patients, most frequently sensory neuropathy (n = 24, 24…
  • Efficacy and Safety of Direct Acting Antivirals for the Treatment of Mixed Cryoglobulinemia. [Journal Article]
    Am J Gastroenterol. 2017 Aug; 112(8):1298-1308.Emery JS, Kuczynski M, … Feld JJ
  • CONCLUSIONS: DAAs resulted in high rates of SVR in patients with cryoglobulinemia. Safety and tolerability were excellent; however, most patients did not have a complete clinical or immunological response, suggesting a delay to clinical response particularly in those with severe/life-threatening vasculitis. Further follow-up will be required to determine if clinical improvement continues after viral clearance.
  • Cryoglobulin Test and Cryoglobulinemia Hepatitis C-Virus Related. [Review]
    Mediterr J Hematol Infect Dis. 2017; 9(1):e2017007.Gulli F, Santini SA, … Basile U
  • Cryoglobulins are immunoglobulins that precipitate in serum at temperatures below 37°C and resolubilize upon warming. The clinical syndrome of cryoglobulinemia usually includes purpura, weakness, and arthralgia, but the underlying disease may also contribute other symptoms. Blood samples for cryoglobulin are collected, transported, clotted and spun at 37°C, before the precipitate is allowed to fo…
  • [A Case of Secondary Cryofibrinogenemia with Cholangiocarcinoma and Deep Venous Thrombosis]. [Case Reports]
    Rinsho Byori. 2015 Apr; 63(4):421-6.Arai S, Sugano M, … Okumura N
  • Cryofibrinogen (CF) is a type of cryoprotein (CP) that can precipitate in cooled plasma but not in serum, and resolves upon warming. We identified a case of secondary cryofibrinogenemia with cholangiocarcinoma and deep venous thrombosis. The patient's cryocrit measured using a Wintrobe tube was 19% in sodium citrate plasma stored for 7 days at 4 degrees C. We performed quantitative analysis of pl…
  • A Case of Cryoglobulinemic Membranoproliferative Glomerulonephritis Induced by Hepatitis C Virus. [Case Reports]
    J Nippon Med Sch. 2015; 82(4):193-201.Otsuka T, Sakai Y, … Tsuruoka S
  • A 61-year-old man with bilateral purpura of the lower limbs and subsequent edema, was hospitalization after renal dysfunction developed. The presence of hepatitis C virus (HCV) RNA and cryoglobulin and the finding of membranoproliferative glomerulonephritis on renal biopsy led to a diagnosis of HCV-related glomerulonephritis due to cryoglobulinemia. Because of the pre-existence of nephrotic syndr…
  • Sjögren Syndrome and Cryoglobulinemic Glomerulonephritis. [Case Reports]
    Am J Kidney Dis. 2015 Sep; 66(3):532-5.Anand A, Krishna GG, … Kambham N
  • We report the case of a 53-year-old woman with Sjögren syndrome and cryoglobulinemia. The patient presented with nephrotic syndrome, hematuria, and reduced estimated glomerular filtration rate. The kidney biopsy revealed diffuse endocapillary proliferation and leukocyte exudation with focal intraluminal hyaline thrombi, prominent tubulointerstitial inflammation, and vasculitis. Diffuse granular m…
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