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(pralidoxime)
1,501 results
  • Myocardial Infarction following Organophosphorus Compound Poisoning. [Case Reports]
    J Assoc Physicians India 2018; 66(12):88-89Ayyadurai P, Subbiah G, Selvaraj V
  • We report a 22 year old male who was admitted to our hospital with alleged history of consumption of monocrotophos poison and had presented with chest pain. His electrocardiogram (ECG) had showed ST segment elevation myocardial infarction and troponins were elevated. He also had low cholinesterase levels and was treated with pralidoxime and atropine and his condition improved. Cardiac catheteriza…
  • Oximes as pretreatment before acute exposure to paraoxon. [Journal Article]
    J Appl Toxicol 2019Lorke DE, Nurulain SM, … Petroianu GA
  • Organophosphates, useful agents as pesticides, also represent a serious danger due to their high acute toxicity. There is indication that oximes, when administered before organophosphate exposure, can protect from these toxic effects. We have tested at equitoxic dosage (25% of LD01) the prophylactic efficacy of five experimental (K-48, K-53, K-74, K-75, K-203) and two established oximes (pralidox…
  • "That's Not His Regular Formula": A Case of Organophosphate Poisoning in an Infant. [Journal Article]
    Pediatr Emerg Care 2019Dodson J, Feng SY, Rodriguez D
  • CONCLUSIONS: Symptoms from OP toxicity are secondary to effects on muscarinic and nicotinic cholinergic receptors in the autonomic and central nervous systems. Symptoms include diaphoresis, diarrhea, urination, miosis, bradycardia, bronchospasm, bronchorrhea, emesis, lethargy, lacrimation, and salivation. Treatment starts with titrated doses of atropine and oximes (eg, pralidoxime) after resuscitation and decontamination. Severity of toxicity and recovery can be monitored via plasma and whole blood acetylcholinesterase levels, respectively. Once aging has occurred, oximes will not be able to reverse acetylcholinesterase inhibition. Despite early treatment, rare cases may result in delayed neurologic complications associated with sensory and motor axonal degeneration of the peripheral nerves and spinal cord known as OP-induced delayed neuropathy.This case highlights the importance of safety education for families. It also demonstrates how to recognize and treat OP toxicity in an infant. It emphasizes starting treatment early to avoid complications secondary to aging.
  • Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure. [Review]
    Chem Biol Interact 2019; 308:194-197Taylor P, Yan-Jye S, … Sharpless KB
  • Since the development in the 1950's of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. Despite seminal advances in detailing the structures of the cholinesterases as the primary target site, progress wi…
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