Fever of unknown origin

DDx

Infection

  • Tuberculosis, endocarditis, osteomyelitis, urinary tract infection, sinusitis, occult abscess (intra-abdominal, dental, brain), cholangitis, primary HIV, Epstein-Barr virus, cytomegalovirus, systemic mycosis, toxoplasmosis, brucellosis, Q fever, cat-scratch disease, salmonellosis, malaria
Neoplasm
  • Hodgkin’s or non-Hodgkin’s lymphoma, leukemia, primary or metastatic liver cancer, renal cell carcinoma, atrial myxoma, others
Autoimmune
  • Adult Still’s disease, systemic lupus erythematosus, cryoglobulinemia, polyarteritis nodosa, temporal (giant cell) arteritis, polymyalgia rheumatica, Wegener’s granulomatosis
Other
  • Drug fever, sarcoidosis, alcoholic or granulomatous hepatitis, Crohn’s disease, ulcerative colitis, factitious fever, thyroiditis, hematoma, recurrent pulmonary emboli, hypersensitivity pneumonitis, familial Mediterranean fever, Whipple’s disease

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