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Cognitive correlates of brain MRI subcortical signal hyperintensities in non-demented elderly.
Int J Geriatr Psychiatry. 2006 Jan; 21(1):32-5.IJ

Abstract

OBJECTIVE

To investigate the relationship between magnetic resonance imaging (MRI) subcortical gray and capsular (SGCH) and white matter hyperintensities (WMH) and cognitive functions in non-demented community dwelling elderly.

METHODS

The severity of SGCH and WMH on proton density and T2 MR images in 16 subjects was scored using the semi-quantitative rating scale of Scheltens et al. (1993). A limited series of cognitive tests selected a priori were then correlated with severity of SGCH and WMH.

RESULTS

Analysis demonstrated that severity of SGCH was inversely related to performance on the Digit Span (R = -0.64, p < 0.01) and the Stroop Color Word Tests (R = -0.64, p < 0.01). Severity of WMH was related to worsening performance on the Trail Making Test (R = 0.67, p < 0.005).

CONCLUSIONS

These findings indicate that severity of WMH is negatively related to more pure executive cognitive functions, specifically set shifting, while severity of SGCH is inversely related to more basic functions of attention and working memory.

Authors+Show Affiliations

Marshall GA
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Hendrickson R
No affiliation info available
Kaufer DI
No affiliation info available
Ivanco LS
No affiliation info available
Bohnen NI
No affiliation info available

MeSH

AgedBasal GangliaBrainCognitionFemaleHumansMagnetic Resonance ImagingMalePsychological Tests

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16323251

Citation

Marshall, Gad A., et al. "Cognitive Correlates of Brain MRI Subcortical Signal Hyperintensities in Non-demented Elderly." International Journal of Geriatric Psychiatry, vol. 21, no. 1, 2006, pp. 32-5.
Marshall GA, Hendrickson R, Kaufer DI, et al. Cognitive correlates of brain MRI subcortical signal hyperintensities in non-demented elderly. Int J Geriatr Psychiatry. 2006;21(1):32-5.
Marshall, G. A., Hendrickson, R., Kaufer, D. I., Ivanco, L. S., & Bohnen, N. I. (2006). Cognitive correlates of brain MRI subcortical signal hyperintensities in non-demented elderly. International Journal of Geriatric Psychiatry, 21(1), 32-5.
Marshall GA, et al. Cognitive Correlates of Brain MRI Subcortical Signal Hyperintensities in Non-demented Elderly. Int J Geriatr Psychiatry. 2006;21(1):32-5. PubMed PMID: 16323251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive correlates of brain MRI subcortical signal hyperintensities in non-demented elderly. AU - Marshall,Gad A, AU - Hendrickson,Rick, AU - Kaufer,Daniel I, AU - Ivanco,Larry S, AU - Bohnen,Nicolaas I, PY - 2005/12/3/pubmed PY - 2006/8/2/medline PY - 2005/12/3/entrez SP - 32 EP - 5 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 21 IS - 1 N2 - OBJECTIVE: To investigate the relationship between magnetic resonance imaging (MRI) subcortical gray and capsular (SGCH) and white matter hyperintensities (WMH) and cognitive functions in non-demented community dwelling elderly. METHODS: The severity of SGCH and WMH on proton density and T2 MR images in 16 subjects was scored using the semi-quantitative rating scale of Scheltens et al. (1993). A limited series of cognitive tests selected a priori were then correlated with severity of SGCH and WMH. RESULTS: Analysis demonstrated that severity of SGCH was inversely related to performance on the Digit Span (R = -0.64, p < 0.01) and the Stroop Color Word Tests (R = -0.64, p < 0.01). Severity of WMH was related to worsening performance on the Trail Making Test (R = 0.67, p < 0.005). CONCLUSIONS: These findings indicate that severity of WMH is negatively related to more pure executive cognitive functions, specifically set shifting, while severity of SGCH is inversely related to more basic functions of attention and working memory. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/16323251/ DB - PRIME DP - Unbound Medicine ER -
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