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[Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice].
Zhong Yao Cai. 2011 Dec; 34(12):1912-5.ZY

Abstract

OBJECTIVE

To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice.

METHODS

Schisandrin in mice plasma and tissues including heart, liver, spleen, lung and kidney was quantitatively determined by HPLC.

RESULTS

The concentration-time curve of Schisandra chinensis extract was described by a single compartment model, Cmax was (2.17 +/- 0.27) mg/ mL, t(max) was (1.00 +/- 0.32) h, AUC0-->infinity, was (4.07 +/- 0.62) mg x h/mL. The sequence of distribution of schisandrin in mice body was as follows: liver > plasma > kidney > lung > heart > spleen.

CONCLUSION

The distribution of extract in the body is abroad. Liver has relative high concentration of schisandrin, which is beneficial to the treatment of hepatic disease.

Authors+Show Affiliations

Guan J
College of Pharmacy, Jilin Medical College, Jilin 132013, China. rainbowguanjiao@sina.com
Zhu HY
No affiliation info available
Zhang XR
No affiliation info available
Zhao Y
No affiliation info available
Sun DY
No affiliation info available

MeSH

Administration, OralAnimalsArea Under CurveChromatography, High Pressure LiquidCyclooctanesFruitKidneyLignansLiverLungMaleMicePlant ExtractsPolycyclic CompoundsSchisandraSpleenTissue Distribution

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22500430

Citation

Guan, Jiao, et al. "[Pharmacokinetics and Tissue Distribution of Schisandra Chinensis Extract in Mice]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 34, no. 12, 2011, pp. 1912-5.
Guan J, Zhu HY, Zhang XR, et al. [Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice]. Zhong Yao Cai. 2011;34(12):1912-5.
Guan, J., Zhu, H. Y., Zhang, X. R., Zhao, Y., & Sun, D. Y. (2011). [Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 34(12), 1912-5.
Guan J, et al. [Pharmacokinetics and Tissue Distribution of Schisandra Chinensis Extract in Mice]. Zhong Yao Cai. 2011;34(12):1912-5. PubMed PMID: 22500430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice]. AU - Guan,Jiao, AU - Zhu,He-Yun, AU - Zhang,Xiu-Rong, AU - Zhao,Yang, AU - Sun,De-Yi, PY - 2012/4/17/entrez PY - 2012/4/17/pubmed PY - 2012/9/21/medline SP - 1912 EP - 5 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 34 IS - 12 N2 - OBJECTIVE: To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice. METHODS: Schisandrin in mice plasma and tissues including heart, liver, spleen, lung and kidney was quantitatively determined by HPLC. RESULTS: The concentration-time curve of Schisandra chinensis extract was described by a single compartment model, Cmax was (2.17 +/- 0.27) mg/ mL, t(max) was (1.00 +/- 0.32) h, AUC0-->infinity, was (4.07 +/- 0.62) mg x h/mL. The sequence of distribution of schisandrin in mice body was as follows: liver > plasma > kidney > lung > heart > spleen. CONCLUSION: The distribution of extract in the body is abroad. Liver has relative high concentration of schisandrin, which is beneficial to the treatment of hepatic disease. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/22500430/ DB - PRIME DP - Unbound Medicine ER -

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