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[SYNCOPE CAUSED BY INTRA-OCULAR TIMOLOL].
Harefuah. 2015 Nov; 154(11):701-2, 742.H

Abstract

INTRODUCTION

Timolol eye-drops are commonly used for the treatment of glaucoma. Despite being topically applied, some systemic absorption occurs with the resulting adverse reactions related to its beta-adrenoreceptor blocking activity

CASE PRESENTATION

We report the case of a 68 years old healthy male who was admitted to our department for further workup following two episodes of syncope. Medical history taking revealed that the episodes of syncope occurred soon after beginning treatment with intra-ocular timolol for glaucoma. An electrocardiogram demonstrated a sinus bradycardia rhythm and a prolonged PR interval, consistent with the negative effects of a beta adrenergic receptor antagonist on the heart's electrical generation and conduction system.

DISCUSSION

This case demonstrates the potential for dangerous systemic side effects of a topically-applied medication. It also highlights the importance of thorough medical history taking in the evaluation of syncope, including inquiry regarding the use of all, especially new, medications.

CONCLUSION

Detailed medical history taking can help in avoiding the performance of an expensive and unnecessary workup.

Authors

Eyal A
No affiliation info available
Braun E
No affiliation info available
Naffaa ME
No affiliation info available

MeSH

Administration, OphthalmicAdrenergic beta-AntagonistsAgedGlaucomaHumansMaleSyncopeTimolol

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

heb

PubMed ID

26821501

Citation

Eyal, Allon, et al. "[SYNCOPE CAUSED BY INTRA-OCULAR TIMOLOL]." Harefuah, vol. 154, no. 11, 2015, pp. 701-2, 742.
Eyal A, Braun E, Naffaa ME. [SYNCOPE CAUSED BY INTRA-OCULAR TIMOLOL]. Harefuah. 2015;154(11):701-2, 742.
Eyal, A., Braun, E., & Naffaa, M. E. (2015). [SYNCOPE CAUSED BY INTRA-OCULAR TIMOLOL]. Harefuah, 154(11), 701-2, 742.
Eyal A, Braun E, Naffaa ME. [SYNCOPE CAUSED BY INTRA-OCULAR TIMOLOL]. Harefuah. 2015;154(11):701-2, 742. PubMed PMID: 26821501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [SYNCOPE CAUSED BY INTRA-OCULAR TIMOLOL]. AU - Eyal,Allon, AU - Braun,Eyal, AU - Naffaa,Mohammad E, PY - 2016/1/30/entrez PY - 2016/1/30/pubmed PY - 2016/2/13/medline SP - 701-2, 742 JF - Harefuah JO - Harefuah VL - 154 IS - 11 N2 - INTRODUCTION: Timolol eye-drops are commonly used for the treatment of glaucoma. Despite being topically applied, some systemic absorption occurs with the resulting adverse reactions related to its beta-adrenoreceptor blocking activity CASE PRESENTATION: We report the case of a 68 years old healthy male who was admitted to our department for further workup following two episodes of syncope. Medical history taking revealed that the episodes of syncope occurred soon after beginning treatment with intra-ocular timolol for glaucoma. An electrocardiogram demonstrated a sinus bradycardia rhythm and a prolonged PR interval, consistent with the negative effects of a beta adrenergic receptor antagonist on the heart's electrical generation and conduction system. DISCUSSION: This case demonstrates the potential for dangerous systemic side effects of a topically-applied medication. It also highlights the importance of thorough medical history taking in the evaluation of syncope, including inquiry regarding the use of all, especially new, medications. CONCLUSION: Detailed medical history taking can help in avoiding the performance of an expensive and unnecessary workup. SN - 0017-7768 UR - https://www.unboundmedicine.com/medline/citation/26821501/ DB - PRIME DP - Unbound Medicine ER -

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