Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia.
Dermatol Surg. 2019 Oct; 45(10):1262-1273.DS

Abstract

BACKGROUND

Platelet-rich plasma (PRP) treatment may encourage hair growth by promoting cellular maturation, differentiation, and proliferation.

OBJECTIVE

The objective of this study was to evaluate the effectiveness of PRP as a treatment for androgenetic alopecia (AGA).

MATERIALS AND METHODS

A literature search combined with meta-analysis was used to calculate the overall standardized mean difference (SMD) in hair density in patients treated with PRP injections in comparison with baseline and placebo treatment. Chi squared analysis and Fisher exact test were used to investigate variation in protocols.

RESULTS

The overall SMD in hair density was 0.58 (95% confidence interval [CI]: 0.35-0.80) and 0.51 (95% CI: 0.23-0.80, p < .0004) in favor of PRP treatment when compared with baseline and placebo treatment, respectively.

CONCLUSION

Platelet-rich plasma is beneficial in the treatment of AGA. It is recommended that 3 monthly sessions of PRP (once monthly ×3 treatments) be used followed by a 3- to 6-month maintenance period.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Gupta AK

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada.

Cole J

Cole Hair Transplant Group, Alpharetta, Georgia.

Deutsch DP

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Bosley Medical, Beverly Hills, California.

Everts PA

EmCyte Corporation, Fort Myers, Florida.

Niedbalski RP

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Northwest Hair Restoration, Tacoma, Washington.

Panchaprateep R

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Rinaldi F

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. International Hair Research Foundation, Italy.

Rose PT

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Hair Transplant Institute Miami, Coral Gables, Florida.

Sinclair R

Sinclair Dermatology, Melbourne, Australia.

Vogel JE

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Division of Plastic Surgery, Department of Surgery, The Johns Hopkins Hospital and School of Medicine, Baltimore, Maryland.

Welter RJ

New England Center for Hair Restoration, Westwood, Massachusetts.

Zufelt MD

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Hair Restoration Center of Utah, Salt Lake City, Utah.

Puig CJ

International Society of Hair Restoration Surgery (ISHRS), Ad Hoc Committee on PRP. Physicians Hair Restoration Center, Houston, Texas.

MeSH

AlopeciaBlood Transfusion, AutologousCell DifferentiationCell ProliferationDose-Response Relationship, DrugDrug Administration ScheduleHairHumansInjections, SubcutaneousMalePlatelet-Rich PlasmaTreatment Outcome

Pub Type(s)

Journal Article

Meta-Analysis

Review

Language

eng

PubMed ID

30882509

Citation

Gupta, Aditya K., et al. "Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia." Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], vol. 45, no. 10, 2019, pp. 1262-1273.

Gupta AK, Cole J, Deutsch DP, et al. Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia. Dermatol Surg. 2019;45(10):1262-1273.

Gupta, A. K., Cole, J., Deutsch, D. P., Everts, P. A., Niedbalski, R. P., Panchaprateep, R., Rinaldi, F., Rose, P. T., Sinclair, R., Vogel, J. E., Welter, R. J., Zufelt, M. D., & Puig, C. J. (2019). Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia. Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.], 45(10), 1262-1273. https://doi.org/10.1097/DSS.0000000000001894

Gupta AK, et al. Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia. Dermatol Surg. 2019;45(10):1262-1273. PubMed PMID: 30882509.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia. AU - Gupta,Aditya K, AU - Cole,John, AU - Deutsch,David P, AU - Everts,Peter A, AU - Niedbalski,Robert P, AU - Panchaprateep,Ratchathorn, AU - Rinaldi,Fabio, AU - Rose,Paul T, AU - Sinclair,Rodney, AU - Vogel,James E, AU - Welter,Ryan J, AU - Zufelt,Michael D, AU - Puig,Carlos J, PY - 2019/3/19/pubmed PY - 2020/1/14/medline PY - 2019/3/19/entrez SP - 1262 EP - 1273 JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JO - Dermatol Surg VL - 45 IS - 10 N2 - BACKGROUND: Platelet-rich plasma (PRP) treatment may encourage hair growth by promoting cellular maturation, differentiation, and proliferation. OBJECTIVE: The objective of this study was to evaluate the effectiveness of PRP as a treatment for androgenetic alopecia (AGA). MATERIALS AND METHODS: A literature search combined with meta-analysis was used to calculate the overall standardized mean difference (SMD) in hair density in patients treated with PRP injections in comparison with baseline and placebo treatment. Chi squared analysis and Fisher exact test were used to investigate variation in protocols. RESULTS: The overall SMD in hair density was 0.58 (95% confidence interval [CI]: 0.35-0.80) and 0.51 (95% CI: 0.23-0.80, p < .0004) in favor of PRP treatment when compared with baseline and placebo treatment, respectively. CONCLUSION: Platelet-rich plasma is beneficial in the treatment of AGA. It is recommended that 3 monthly sessions of PRP (once monthly ×3 treatments) be used followed by a 3- to 6-month maintenance period. SN - 1524-4725 UR - https://www.unboundmedicine.com/medline/citation/30882509/ DB - PRIME DP - Unbound Medicine ER -

Tags

Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia.Dermatol Surg. 2019 Oct; 45(10):1262-1273.DS