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Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades.
Clin Drug Investig. 2019 Sep; 39(9):865-872.CD

Abstract

BACKGROUND AND OBJECTIVES

Platelet-rich plasma (PRP) has received growing attention as a valuable therapeutic tool in androgenetic alopecia (AGA). However, knowledge regarding specific effectiveness and satisfaction of PRP for different grades of AGA in male pattern hair loss (MPHL) and female pattern hair loss (FPHL) is missing. This study aims to ascertain and compare the efficacy and safety of PRP treatment for different grades of AGA in males and females over 6 months.

METHODS

In this study, 51 MPHL patients with Norwood-Hamilton stage II-V and 42 FPHL patients with Ludwig stage I to III were enrolled for 6 monthly sessions of PRP injections. A longitudinal analysis was used to compare the hair density, thickness, and hair pull test over 6 months for MPHL and FPHL through generalized estimating equation (GEE) models. Phototrichograms of scalp inflammation and oil secretion, global photographs and overall patient satisfaction were also assessed.

RESULTS

Consequently, improvement of hair density, hair thickness, hair pull test, the level of scalp inflammation and oil secretion were observed with statistical significance in all stages for both MPHL and FPHL at 6 months. Noteworthy, lower level of alopecia (Grade II, III in MPHL and Grade I in FPHL) had better response to PRP, and also had a better tendency of increment of hair growth than that of high-grade patients with prolonged treatment.

CONCLUSIONS

PRP injections, as an efficacious and reliable therapy, can be recommended for Grade II and Grade III in MPHL and Grade I in FPHL.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China. 13265031995@163.com.

Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong Province, China. doctorhzqnew@163.com.

MeSH

AdultAlopeciaFemaleHairHumansMaleMiddle AgedPatient SatisfactionPlatelet-Rich PlasmaSeverity of Illness Index

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31228018

Citation

Qu, Qian, et al. "Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades." Clinical Drug Investigation, vol. 39, no. 9, 2019, pp. 865-872.

Qu Q, Shi P, Yi Y, et al. Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades. Clin Drug Investig. 2019;39(9):865-872.

Qu, Q., Shi, P., Yi, Y., Fan, Z., Liu, X., Zhu, D., Chen, J., Ye, K., Miao, Y., & Hu, Z. (2019). Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades. Clinical Drug Investigation, 39(9), 865-872. https://doi.org/10.1007/s40261-019-00806-4

Qu Q, et al. Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades. Clin Drug Investig. 2019;39(9):865-872. PubMed PMID: 31228018.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades. AU - Qu,Qian, AU - Shi,Panli, AU - Yi,Yanhua, AU - Fan,Zhexiang, AU - Liu,Xiaomin, AU - Zhu,Decong, AU - Chen,Jian, AU - Ye,Ke, AU - Miao,Yong, AU - Hu,Zhiqi, PY - 2019/6/23/pubmed PY - 2020/1/3/medline PY - 2019/6/23/entrez SP - 865 EP - 872 JF - Clinical drug investigation JO - Clin Drug Investig VL - 39 IS - 9 N2 - BACKGROUND AND OBJECTIVES: Platelet-rich plasma (PRP) has received growing attention as a valuable therapeutic tool in androgenetic alopecia (AGA). However, knowledge regarding specific effectiveness and satisfaction of PRP for different grades of AGA in male pattern hair loss (MPHL) and female pattern hair loss (FPHL) is missing. This study aims to ascertain and compare the efficacy and safety of PRP treatment for different grades of AGA in males and females over 6 months. METHODS: In this study, 51 MPHL patients with Norwood-Hamilton stage II-V and 42 FPHL patients with Ludwig stage I to III were enrolled for 6 monthly sessions of PRP injections. A longitudinal analysis was used to compare the hair density, thickness, and hair pull test over 6 months for MPHL and FPHL through generalized estimating equation (GEE) models. Phototrichograms of scalp inflammation and oil secretion, global photographs and overall patient satisfaction were also assessed. RESULTS: Consequently, improvement of hair density, hair thickness, hair pull test, the level of scalp inflammation and oil secretion were observed with statistical significance in all stages for both MPHL and FPHL at 6 months. Noteworthy, lower level of alopecia (Grade II, III in MPHL and Grade I in FPHL) had better response to PRP, and also had a better tendency of increment of hair growth than that of high-grade patients with prolonged treatment. CONCLUSIONS: PRP injections, as an efficacious and reliable therapy, can be recommended for Grade II and Grade III in MPHL and Grade I in FPHL. SN - 1179-1918 UR - https://www.unboundmedicine.com/medline/citation/31228018/ DB - PRIME DP - Unbound Medicine ER -