TY - JOUR T1 - Comparison of interlaminar CT-guided epidural platelet-rich plasma versus steroid injection in patients with lumbar radicular pain. AU - Bise,Sylvain, AU - Dallaudiere,Benjamin, AU - Pesquer,Lionel, AU - Pedram,Morad, AU - Meyer,Philippe, AU - Antoun,Myriame Bou, AU - Hocquelet,Arnaud, AU - Silvestre,Alain, Y1 - 2020/02/24/ PY - 2019/06/12/received PY - 2020/02/07/accepted PY - 2020/01/27/revised PY - 2020/2/26/pubmed PY - 2020/11/18/medline PY - 2020/2/26/entrez KW - Back pain KW - Lumbar KW - Platelet-rich plasma KW - Regenerative KW - Spine (Phila Pa 1976) SP - 3152 EP - 3160 JF - European radiology JO - Eur Radiol VL - 30 IS - 6 N2 - INTRODUCTION: The treatment of persistent lumbar radicular pain (LRP) by CT-guided epidural steroid injection (ESI) is extensively used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to favor healing and the anti-inflammatory process by delivering growth factors and cytokines, might be an alternative and potentially safer option. We compared the efficacy of interlaminar CT-guided epidural PRP injections (EPRPI) and ESI in the treatment of persistent LRP (> 6 weeks). METHODS: In this non-randomized comparative study, patients were prospectively assessed for pain using the numerical rating scale (NRS) and for function with the Oswestry Disability Index (ODI) before and 6 weeks after treatment. Related paired and independent t tests were used for intra- and inter-group comparisons. RESULTS: A total of 60 patients were included in 2 groups (n = 30 EPRPI, n = 30 ESI). A statistically significant improvement was found in both groups at 6 weeks (mean NRS values 5.7 (± 2.36) at D0 and 3.7 (± 2.3) at 6 weeks (p < 0.01); mean ODI values 30 (± 11) at D0 and 21 (± 13) at 6 weeks (p < 0.01)). No significant difference was observed in the decrease in NRS and ODI scores between the 2 groups at 6 weeks (p = 0.848 and p = 0.314 for the NRS and ODI, respectively). No major complications were noted. CONCLUSION: The results of CT-guided interlaminar EPRPI are similar to ESI for the treatment of persistent LRP and could be a safer option. KEY POINTS: • Treatment of persistent lumbar radicular pain by CT-guided epidural steroid injections is associated with rare but serious complications. • By promoting an anti-inflammatory process, epidural platelet-rich plasma injections might be an alternative treatment of persistent radicular pain. • Platelet-rich plasma CT-guided epidural injections are similar to steroid for the treatment of lumbar radicular pain at 6 weeks post-procedure and could be a safer option. SN - 1432-1084 UR - https://www.unboundmedicine.com/medline/citation/32095875/ DB - PRIME DP - Unbound Medicine ER -