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Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation.
Sci Adv. 2020 Oct; 6(43)SA

Abstract

Poor wound healing after diabetes or extensive burn remains a challenging problem. Recently, we presented a physical approach to fabricate ultrasmall silver particles from Ångstrom scale to nanoscale and determined the antitumor efficacy of Ångstrom-scale silver particles (AgÅPs) in the smallest size range. Here we used the medium-sized AgÅPs (65.9 ± 31.6 Å) to prepare carbomer gel incorporated with these larger AgÅPs (L-AgÅPs-gel) and demonstrated the potent broad-spectrum antibacterial activity of L-AgÅPs-gel without obvious toxicity on wound healing-related cells. Induction of reactive oxygen species contributed to L-AgÅPs-gel-induced bacterial death. Topical application of L-AgÅPs-gel to mouse skin triggered much stronger effects than the commercial silver nanoparticles (AgNPs)-gel to prevent bacterial colonization, reduce inflammation, and accelerate diabetic and burn wound healing. L-AgÅPs were distributed locally in skin without inducing systemic toxicities. This study suggests that L-AgÅPs-gel represents an effective and safe antibacterial and anti-inflammatory material for wound therapy.

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Chen CY
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China.
Yin H
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China.
Chen X
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Chen TH
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Liu HM
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Rao SS
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Xiangya School of Nursing, Central South University, Changsha, Hunan 410013, China.
Tan YJ
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China.
Qian YX
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Liu YW
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Hu XK
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Luo MJ
Xiangya School of Nursing, Central South University, Changsha, Hunan 410013, China.
Wang ZX
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China.
Liu ZZ
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Cao J
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
He ZH
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Wu B
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yue T
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Wang YY
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xia K
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Luo ZW
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Wang Y
Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China. Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Situ WY
Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China.
Liu WE
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Tang SY
Xiangya School of Nursing, Central South University, Changsha, Hunan 410013, China.
Xie H
Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. huixie@csu.edu.cn. Angmedicine Research Center of Central South University, Changsha, Hunan 410008, China. Xiangya Hospital of Central South University-Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China. Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, Hunan 410008, China. Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, Hunan 410008, China.

MeSH

Acrylic ResinsAnimalsAnti-Bacterial AgentsBurnsInflammationMetal NanoparticlesMiceSilverWound Healing

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33097529

Citation

Chen, Chun-Yuan, et al. "Ångstrom-scale Silver Particle-embedded Carbomer Gel Promotes Wound Healing By Inhibiting Bacterial Colonization and Inflammation." Science Advances, vol. 6, no. 43, 2020.
Chen CY, Yin H, Chen X, et al. Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation. Sci Adv. 2020;6(43).
Chen, C. Y., Yin, H., Chen, X., Chen, T. H., Liu, H. M., Rao, S. S., Tan, Y. J., Qian, Y. X., Liu, Y. W., Hu, X. K., Luo, M. J., Wang, Z. X., Liu, Z. Z., Cao, J., He, Z. H., Wu, B., Yue, T., Wang, Y. Y., Xia, K., ... Xie, H. (2020). Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation. Science Advances, 6(43). https://doi.org/10.1126/sciadv.aba0942
Chen CY, et al. Ångstrom-scale Silver Particle-embedded Carbomer Gel Promotes Wound Healing By Inhibiting Bacterial Colonization and Inflammation. Sci Adv. 2020;6(43) PubMed PMID: 33097529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation. AU - Chen,Chun-Yuan, AU - Yin,Hao, AU - Chen,Xia, AU - Chen,Tuan-Hui, AU - Liu,Hao-Ming, AU - Rao,Shan-Shan, AU - Tan,Yi-Juan, AU - Qian,Yu-Xuan, AU - Liu,Yi-Wei, AU - Hu,Xiong-Ke, AU - Luo,Ming-Jie, AU - Wang,Zhen-Xing, AU - Liu,Zheng-Zhao, AU - Cao,Jia, AU - He,Ze-Hui, AU - Wu,Ben, AU - Yue,Tao, AU - Wang,Yi-Yi, AU - Xia,Kun, AU - Luo,Zhong-Wei, AU - Wang,Yang, AU - Situ,Wei-Yi, AU - Liu,Wen-En, AU - Tang,Si-Yuan, AU - Xie,Hui, Y1 - 2020/10/23/ PY - 2019/11/04/received PY - 2020/09/03/accepted PY - 2020/10/24/entrez PY - 2020/10/25/pubmed PY - 2022/4/14/medline JF - Science advances JO - Sci Adv VL - 6 IS - 43 N2 - Poor wound healing after diabetes or extensive burn remains a challenging problem. Recently, we presented a physical approach to fabricate ultrasmall silver particles from Ångstrom scale to nanoscale and determined the antitumor efficacy of Ångstrom-scale silver particles (AgÅPs) in the smallest size range. Here we used the medium-sized AgÅPs (65.9 ± 31.6 Å) to prepare carbomer gel incorporated with these larger AgÅPs (L-AgÅPs-gel) and demonstrated the potent broad-spectrum antibacterial activity of L-AgÅPs-gel without obvious toxicity on wound healing-related cells. Induction of reactive oxygen species contributed to L-AgÅPs-gel-induced bacterial death. Topical application of L-AgÅPs-gel to mouse skin triggered much stronger effects than the commercial silver nanoparticles (AgNPs)-gel to prevent bacterial colonization, reduce inflammation, and accelerate diabetic and burn wound healing. L-AgÅPs were distributed locally in skin without inducing systemic toxicities. This study suggests that L-AgÅPs-gel represents an effective and safe antibacterial and anti-inflammatory material for wound therapy. SN - 2375-2548 UR - https://www.unboundmedicine.com/medline/citation/33097529/ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓52 ↑39]

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