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Regenerative Medicine for Knee Osteoarthritis - The Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: A Literature Review.
Cureus. 2020 Sep 21; 12(9):e10575.C

Abstract

The prevalence of osteoarthritis (OA) has been rising exponentially in recent years. As the disease progresses, patients may eventually require surgical intervention to restore the functionality of the affected knees. The current literature review aims to explore two treatment options in regenerative medicine for OA by analyzing the efficacy and safety of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) use, as well as determining which population will benefit from these treatments. A total of 1093 patients who were diagnosed with unilateral or bilateral knee osteoarthritis (KOA) were recruited in 23 studies. The experimental groups received either PRP or MSCs injections in comparison to the control groups receiving either hyaluronic acid (HA) or placebo (saline or dextrose) injections. Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to evaluate all participants at different time intervals of the studies. Medical imaging evaluations (X-ray or MRI) were used to look for structural improvements. In conclusion, both PRP and MSCs treatments were well tolerated, effective and safe to use. Repeated administrations and higher concentrations resulted in superior clinical improvements. A decrease in cartilage loss was observed in some MSCs trials. No severe adverse effects were documented. PRP treatment proved to be more efficacious among patients with KOA Kellgren-Lawrence (KL) grade I-II, while MSCs treatment proved to be more beneficial among the KOA KL grade II-III group.

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Authors+Show Affiliations

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

33101819

Citation

Ip, Hoi Leng, et al. "Regenerative Medicine for Knee Osteoarthritis - the Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: a Literature Review." Cureus, vol. 12, no. 9, 2020, pp. e10575.

Ip HL, Nath DK, Sawleh SH, et al. Regenerative Medicine for Knee Osteoarthritis - The Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: A Literature Review. Cureus. 2020;12(9):e10575.

Ip, H. L., Nath, D. K., Sawleh, S. H., Kabir, M. H., & Jahan, N. (2020). Regenerative Medicine for Knee Osteoarthritis - The Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: A Literature Review. Cureus, 12(9), e10575. https://doi.org/10.7759/cureus.10575

Ip HL, et al. Regenerative Medicine for Knee Osteoarthritis - the Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: a Literature Review. Cureus. 2020 Sep 21;12(9):e10575. PubMed PMID: 33101819.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Regenerative Medicine for Knee Osteoarthritis - The Efficacy and Safety of Intra-Articular Platelet-Rich Plasma and Mesenchymal Stem Cells Injections: A Literature Review. AU - Ip,Hoi Leng, AU - Nath,Debashis Kumar, AU - Sawleh,Safia H, AU - Kabir,Md Humayun, AU - Jahan,Nusrat, Y1 - 2020/09/21/ PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2020/10/27/medline KW - adipose tissue KW - autologous conditioned plasma KW - bone marrow KW - intra articular injection KW - knee osteoarthritis KW - mesenchymal stem cells KW - platelet-rich plasma KW - regenerative medicine KW - umbilical cord KW - western ontario and mcmaster universities arthritis index (womac) SP - e10575 EP - e10575 JF - Cureus JO - Cureus VL - 12 IS - 9 N2 - The prevalence of osteoarthritis (OA) has been rising exponentially in recent years. As the disease progresses, patients may eventually require surgical intervention to restore the functionality of the affected knees. The current literature review aims to explore two treatment options in regenerative medicine for OA by analyzing the efficacy and safety of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) use, as well as determining which population will benefit from these treatments. A total of 1093 patients who were diagnosed with unilateral or bilateral knee osteoarthritis (KOA) were recruited in 23 studies. The experimental groups received either PRP or MSCs injections in comparison to the control groups receiving either hyaluronic acid (HA) or placebo (saline or dextrose) injections. Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to evaluate all participants at different time intervals of the studies. Medical imaging evaluations (X-ray or MRI) were used to look for structural improvements. In conclusion, both PRP and MSCs treatments were well tolerated, effective and safe to use. Repeated administrations and higher concentrations resulted in superior clinical improvements. A decrease in cartilage loss was observed in some MSCs trials. No severe adverse effects were documented. PRP treatment proved to be more efficacious among patients with KOA Kellgren-Lawrence (KL) grade I-II, while MSCs treatment proved to be more beneficial among the KOA KL grade II-III group. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/33101819/ DB - PRIME DP - Unbound Medicine ER -