TY - JOUR T1 - [Update 2025 of the S3 guidelines: "Sepsis-Prevention, diagnosis, treatment and follow-up care" : What is new?] AU - Neumann,Caroline, AU - Ebert,Daniel, AU - Bucher,Michael, AU - Bauer,Michael, Y1 - 2025/10/30/ PY - 2025/08/11/received PY - 2025/10/14/accepted PY - 2025/11/27/medline PY - 2025/10/30/pubmed PY - 2025/10/30/entrez KW - Adjunctive therapy KW - Screening KW - Sepsis KW - Septic shock KW - Supportive measures SP - 827 EP - 838 JF - Die Anaesthesiologie JO - Anaesthesiologie VL - 74 IS - 12 N2 - The update of the S3 guidelines "Sepsis-Prevention, diagnosis, treatment and follow-up care" was published on 25 July 2025. The new guidelines address 29 new and 16 revised recommendations, with 43 recommendations remaining unchanged from the previous version. The 2025 update is a targeted adaptation of the internationally recognized recommendations of the Surviving Sepsis Campaign from 2021. The focus is on early individualized and evidence-based treatment, the integration of structured follow-up care after hospital discharge and a stronger focus on patient-centered comprehensive care beyond acute treatment. Despite advances in early detection, antibiotic treatment and intensive medical care of patients, sepsis and septic shock remain potentially life-threatening conditions, underlining the necessity for early diagnosis and the initiation of appropriate treatment. SN - 2731-6866 UR - https://www.unboundmedicine.com/medline/citation/41165840/ DB - PRIME DP - Unbound Medicine ER -