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[The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin].
Rev Med Chir Soc Med Nat Iasi. 1996 Jan-Jun; 100(1-2):167-71.RM

Abstract

This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans.

Authors+Show Affiliations

Dorneanu M
Faculté de Pharmacie, Université de Médecine et de Pharmacie Gr. T. Popa, Iaşi.
Stefănescu E
No affiliation info available
Păduraru O
No affiliation info available
Pavelescu M
No affiliation info available
Hriscu A
No affiliation info available

MeSH

AnimalsAnti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsCandida albicansCarrageenanChemical PhenomenaChemistry, PhysicalDrug Evaluation, PreclinicalEscherichia coliHydrazinesHydrazonesInflammationIsatinMicePyridazinesStaphylococcus aureusStructure-Activity Relationship

Pub Type(s)

Journal Article

Language

fre

PubMed ID

9455421

Citation

Dorneanu, M, et al. "[The Reaction of 3-(R-phenyl)-6-hydrazine Pyridazine With 5-methylisatin and 1-morpholinomethyl-5-methylisatin]." Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, vol. 100, no. 1-2, 1996, pp. 167-71.
Dorneanu M, Stefănescu E, Păduraru O, et al. [The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin]. Rev Med Chir Soc Med Nat Iasi. 1996;100(1-2):167-71.
Dorneanu, M., Stefănescu, E., Păduraru, O., Pavelescu, M., & Hriscu, A. (1996). [The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin]. Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, 100(1-2), 167-71.
Dorneanu M, et al. [The Reaction of 3-(R-phenyl)-6-hydrazine Pyridazine With 5-methylisatin and 1-morpholinomethyl-5-methylisatin]. Rev Med Chir Soc Med Nat Iasi. 1996 Jan-Jun;100(1-2):167-71. PubMed PMID: 9455421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin]. AU - Dorneanu,M, AU - Stefănescu,E, AU - Păduraru,O, AU - Pavelescu,M, AU - Hriscu,A, PY - 1996/1/1/pubmed PY - 1998/2/10/medline PY - 1996/1/1/entrez SP - 167 EP - 71 JF - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi JO - Rev Med Chir Soc Med Nat Iasi VL - 100 IS - 1-2 N2 - This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans. SN - 0048-7848 UR - https://www.unboundmedicine.com/medline/citation/9455421/ DB - PRIME DP - Unbound Medicine ER -

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